| Urinary albumin excretion is related to cardiovascular risk indicators, not to flow-mediated vasodilation, in apparently healthy subjects. | |
| | |
MedLine Citation:
|
PMID: 12048129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Based on studies in diabetic and hypertensive populations it has been postulated that early endothelial dysfunction is the mechanism responsible for the increased cardiovascular risk in microalbuminuric subjects. We evaluated the relation between microalbuminuria and endothelial dysfunction, assessed as flow-mediated dilation of the brachial artery, in an apparently healthy population. Within the framework of the PREVEND Intervention Trial non-hypertensive and non-hypercholesterolemic subjects were recruited on the basis of reproducible microalbuminuria. Using high-resolution ultrasound, flow-mediated dilation and nitroglycerin-mediated dilation of the brachial artery was assessed to measure endothelium-dependent and endothelium-independent responses, respectively. For the current study subjects with diabetes mellitus, clinical atherosclerosis, and macroalbuminuria were excluded from the analyses. We studied 421 men and 233 women (mean age (SD) 50 (12)). Increasing levels of urinary albumin excretion were accompanied by a significant increase in age, percentage men, systolic and diastolic blood pressure, body mass index, and serum triglycerides, whereas there was no decrease of flow-mediated vasodilation or nitroglycerin-mediated vasodilation. Adjusted for age and sex, urinary albumin excretion was significantly related to systolic (r=0.19, P<0.001) and diastolic (r=0.16, P<0.001) blood pressure, body mass index (r=0.18, P<0.001), and triglycerides (r=0.13, P=0.001), but not to flow-mediated vasodilation (r=-0.01, P=0.8). In contrast to blood pressure, body mass index, and triglycerides, there was no relation between urinary albumin excretion and flow-mediated vasodilation in apparently healthy subjects. These data suggest that the presence of atherogenic risk factors precedes the development of endothelial dysfunction in microalbuminuric, but otherwise healthy subjects. |
| | |
Authors:
|
Gilles F H Diercks; Erik S G Stroes; Ad J van Boven; Arie M van Roon; Hans L Hillege; P E de Jong; Andries J Smit; Rijk O B Gans; Harry J G M Crijns; Ton J Rabelink; Wiek H van Gilst |
Related Documents
:
|
20429689 - Lack of regression of left ventricular hypertrophy is associated with higher incidence ... 19730439 - Non-dipping pattern in ambulatory blood pressure monitoring is associated with metaboli... 19576149 - Anthropometric and metabolic indicators in hypertensive patients. 11910299 - The influence of zygosity status on blood pressure and on lipid profiles in male and fe... 4835509 - Long term results of gastrectomy with respect to blood lipids, blood pressure, weight a... 22803549 - Anomalous structural phase transition properties in rese(2) and au-doped rese(2). 21736449 - Age dependency of central and peripheral systolic blood pressures: cross-sectional and ... 9710529 - Noradrenaline release in the rat subfornical organ area to blood pressure changes. 2530009 - Determinants of left ventricular hypertrophy in patients with aortic stenosis. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Atherosclerosis Volume: 163 ISSN: 0021-9150 ISO Abbreviation: Atherosclerosis Publication Date: 2002 Jul |
Date Detail:
|
Created Date: 2002-06-05 Completed Date: 2002-12-05 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
|
Languages: eng Pagination: 121-6 Citation Subset: IM |
Affiliation:
|
Department of Clinical Pharmacology, University of Groningen, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands. g.f.h.diercks@med.rug.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Age Factors Albuminuria / diagnosis* Blood Flow Velocity Brachial Artery / pathology, physiopathology Cardiovascular Diseases / epidemiology, etiology*, ultrasonography Endothelium, Vascular / ultrasonography Female Humans Male Middle Aged Probability Prospective Studies Reference Values Risk Assessment Risk Factors Sensitivity and Specificity Sex Factors Urinalysis Vasodilation / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Change in saturated fat intake is associated with progression of carotid and femoral intima-media th...
Next Document: Activity and concentration of lipoprotein lipase in post-heparin plasma and the extent of coronary a...