Document Detail

Urinary albumin excretion among nondipper hypertensive patients is closely related with the pattern of nondipping.
MedLine Citation:
PMID:  20655503     Owner:  NLM     Status:  MEDLINE    
The relationship between 24-hour urinary albumin excretion (UAE) rate and the pattern of nondipping (isolated systolic nondipping, isolated diastolic nondipping, and both systolic and diastolic nondipping) is not known. Medical history, physical examination, laboratory analysis, and office and ambulatory blood pressure measurements were performed. Twenty-four hour urine specimens were collected to determine creatinine clearance and UAE. In total, 158 essential hypertensive patients (104 dippers, 54 nondippers) were included. Fourteen patients were isolated systolic nondippers, 7 patients were isolated diastolic nondippers, and 33 patients were both systolic and diastolic nondippers. Among nondipper patients, 17 had microalbuminuria and, among dipper patients, 9 had microalbuminuria (P<.0001). The median UAE of dippers was lower when compared with nondippers (5.25 mg/day vs.23 mg/day, P<.0001). The median UAE of isolated systolic nondippers, isolated diastolic nondippers, and both systolic and diastolic nondippers were 8.45 mg/day, 7.7 mg/day, and 25.5 mg/day, respectively (P=.001). Subgroup comparison of patients revealed that UAE was higher in patients with both systolic and diastolic nondippers when compared with dippers (P<.0001), isolated systolic nondippers (P=.001), and isolated diastolic nondippers (P=.017). Not only nondipping itself, but nondipping profile may be related with UAE in essential hypertensive patients.
Baris Afsar; Rengin Elsurer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Society of Hypertension : JASH     Volume:  4     ISSN:  1933-1711     ISO Abbreviation:  J Am Soc Hypertens     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-10-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101312518     Medline TA:  J Am Soc Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  196-202     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 American Society of Hypertension. Published by Elsevier Inc. All rights reserved.
Department of Nephrology, Zonguldak Atatürk State Hospital, Zonguldak, Turkey.
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MeSH Terms
Albuminuria / epidemiology*
Blood Pressure Monitoring, Ambulatory
Circadian Rhythm / physiology
Creatinine / urine
Diastole / physiology
Hypertension / epidemiology*,  physiopathology*
Middle Aged
Systole / physiology
Reg. No./Substance:

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