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Urinary UMOD Excretion and Chronic Kidney Disease in Gout Patients: Cross-Sectional Case-Control Study.
MedLine Citation:
PMID:  21332338     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Patients with gout often have concurrent chronic kidney disease (CKD); the relationship between the two conditions is still unclear. Previous studies have identified an association between low level of urinary uromodulin (UMOD) and CKD within the setting of diabetes and lupus. The aim of this study was to examine the association between urinary UMOD excretion and CKD in patients with gout. A total of 53 Taiwanese gout patients with stable disease activity were enrolled. Patients were divided into a CKD group (n = 25) and a non-CKD group (n = 28). Using Pearson correlation analysis, urinary UMOD excretion was positively correlated with estimated glomerular filtration rate (Ha: ρ > 0, p = 0.004). Using multivariate analysis, patients with CKD and gout were associated with lower urinary UMOD excretion than those who have gout alone [odds ratio (95% CI): 0.826 (0.694-0.985), p < 0.001]. Patients with CKD and gout were also more likely to be older (p < 0.001) and have higher uric acid levels (p < 0.001). This study implicates that UMOD might play a role in the relationship between gout and CKD. Further studies with animal models of gout and CKD would be recommended.
Authors:
Chien-Hsing Wu; Chien-Te Lee; Chih-Hsiung Lee; Tien-Tsai Cheng; Hsueh-Wen Chang; Eton Lin; Feng-Rong Chuang; Hui-Ping Yang; Ying-Chou Chen; Chien-Yi Wu; Chung-Jen Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Renal failure     Volume:  33     ISSN:  1525-6049     ISO Abbreviation:  Ren Fail     Publication Date:  2011  
Date Detail:
Created Date:  2011-02-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  England    
Other Details:
Languages:  eng     Pagination:  164-8     Citation Subset:  IM    
Affiliation:
Division of Nephrology, Chang Gung Memorial Hospital - Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
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