Document Detail


Urinary sodium is a potent correlate of proteinuria: lessons from the chronic renal insufficiency cohort study.
MedLine Citation:
PMID:  23076013     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: While higher blood pressure is known to increase proteinuria, whether increased dietary sodium as estimated from 24-hour urinary excretion correlates with increased proteinuria in patients with chronic kidney disease (CKD) is not well studied.
METHODS: We measured 24-hour urinary sodium, potassium and protein excretion in 3,680 participants in the Chronic Renal Insufficiency Cohort study, to determine the relationship between urinary sodium and potassium and urinary protein excretion in patients with CKD. We stratified our data based on the presence or absence of diabetes given the absence of any data on this relationship and evidence that diabetics had greater urinary protein excretion at nearly every level of urinary sodium excretion. Multiple linear regressions were used with a stepwise inclusion of covariates such as systolic blood pressure, demographics, hemoglobin A1c and type of antihypertensive medications to evaluate the relationship between urinary electrolyte excretion and proteinuria.
RESULTS: Our data demonstrated that urinary sodium (+1 SD above the mean), as a univariate variable, explained 12% of the variation in proteinuria (β = 0.29, p < 0.0001), with rising urinary sodium excretion associated with increasing proteinuria. The significance of that relationship was only partially attenuated with adjustment for demographic and clinical factors and the addition of 24-hour urinary potassium to the model (β = 0.13, R(2) = 0.35, p < 0.0001).
CONCLUSIONS: An understanding of the relationship between these clinical factors and dietary sodium may allow a more tailored approach for dietary salt restriction in patients with CKD.
Authors:
Matthew R Weir; Raymond R Townsend; Jeffrey C Fink; Valerie Teal; Stephen M Sozio; Cheryl A Anderson; Lawrence J Appel; Sharon Turban; Jing Chen; Jiang He; Natasha Litbarg; Akinlolu Ojo; Mahboob Rahman; Leigh Rosen; Susan Steigerwalt; Louise Strauss; Marshall M Joffe
Related Documents :
2319633 - The cardiorespiratory effects of intrathecal xylazine in the conscious rabbit.
6140393 - Transdermal continuous antihypertensive therapy.
2145733 - Delayed decline in plasma atrial natriuretic peptide levels after an abrupt reduction i...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-10-12
Journal Detail:
Title:  American journal of nephrology     Volume:  36     ISSN:  1421-9670     ISO Abbreviation:  Am. J. Nephrol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-27     Completed Date:  2013-05-13     Revised Date:  2013-09-24    
Medline Journal Info:
Nlm Unique ID:  8109361     Medline TA:  Am J Nephrol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  397-404     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Affiliation:
University of Maryland School of Medicine, Baltimore, MD, USA. mweir@medicine.umaryland.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Female
Humans
Male
Middle Aged
Proteinuria / complications,  urine*
Regression Analysis
Renal Insufficiency, Chronic / complications,  urine
Sodium / urine*
Grant Support
ID/Acronym/Agency:
M01 RR-000042/RR/NCRR NIH HHS; M01 RR-16500/RR/NCRR NIH HHS; M01 RR016500/RR/NCRR NIH HHS; RR-05096/RR/NCRR NIH HHS; UL1 RR-024131/RR/NCRR NIH HHS; UL1 RR-024134/RR/NCRR NIH HHS; UL1 RR-024986/RR/NCRR NIH HHS; UL1 RR-024989/RR/NCRR NIH HHS; UL1 RR-025005/RR/NCRR NIH HHS; UL1 RR024989/RR/NCRR NIH HHS; UL1 RR029879/RR/NCRR NIH HHS; UL1RR029879/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Modulation of the current signatures of DNA abasic site adducts in the ?-hemolysin ion channel.
Next Document:  [Bacterial susceptibility testings of the lower airways of diseased dogs].