Document Detail

Urinary nitrate, thiocyanate, and perchlorate and serum thyroid endpoints based on NHANES 2001 to 2002.
MedLine Citation:
PMID:  23018524     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine, on the basis of iodide uptake inhibition (IUI), whether associations between urinary concentrations of IUI agents (perchlorate, nitrate, and thiocyanate), as total perchlorate equivalent concentration (PEC), and serum thyroid parameters suggest functional thyroid abnormalities. Additional thyroid hormone measures were released to augment the National Health and Examination Survey (NHANES) 2001 to 2002 data set, which we used in this study.
METHODS: Enhanced thyroid hormone measures released to augment the National Health and Examination Survey (NHANES) 2001-2002 data set were used in this study. Multiple regression was used to assess the relationships among total thyroxine (TT4), free thyroxine, total triiodothyronine (TT3), free triiodothyronine, and thyroid- stimulating hormone (TSH) and PEC.
RESULTS: PEC was weakly and negatively associated with TT4, but not with TSH, TT3, or free hormone. This association with TT4 appears to be dominated by nitrate and thiocyanate.
CONCLUSION: No evidence of functional thyroid abnormality (eg., low thyroid hormone coupled with high TSH) was seen with exposure to the combined IUI agents and enhanced estimates of thyroid function.
Gretchen M Bruce; Lisa M Corey; Jeffrey H Mandel; Richard C Pleus
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine     Volume:  55     ISSN:  1536-5948     ISO Abbreviation:  J. Occup. Environ. Med.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-08     Completed Date:  2013-08-01     Revised Date:  2014-05-14    
Medline Journal Info:
Nlm Unique ID:  9504688     Medline TA:  J Occup Environ Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  52-8     Citation Subset:  IM    
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MeSH Terms
Biological Markers / metabolism
Cohort Studies
Databases, Factual
Environmental Pollutants / adverse effects*
Iodine / urine
Middle Aged
Multivariate Analysis
Nitrates / urine*
Perchlorates / urine*
Regression Analysis
Sensitivity and Specificity
Thiocyanates / urine*
Thyroid Diseases / blood*,  diagnosis,  urine
Thyroid Function Tests
Thyroid Hormones / secretion*
Young Adult
Reg. No./Substance:
0/Biological Markers; 0/Environmental Pollutants; 0/Nitrates; 0/Perchlorates; 0/Thiocyanates; 0/Thyroid Hormones; 302-04-5/thiocyanate; 9679TC07X4/Iodine; VLA4NZX2P4/perchlorate
Comment In:
J Occup Environ Med. 2014 Apr;56(4):e14   [PMID:  24709770 ]
J Occup Environ Med. 2013 Dec;55(12):1385-6   [PMID:  24316723 ]

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