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Urinary NT-proBNP and ductal closure in preterm infants.
MedLine Citation:
PMID:  22743407     Owner:  NLM     Status:  Publisher    
Objective:To explore the association of urinary N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations and closure of patent ductus arteriosus (PDA) in preterm infants.Study design:Blinded prospective study involving 136 preterm infants (median (interquartile range) gestational age 28 (26 to 30) weeks; birth weight 1030 (780 to 1270) g). NT-proBNP was determined in urine collected on day of life (DOL) 2, 7, 14 and 28.Result:Urinary NT-proBNP/creatinine ratios declined continuously between DOL 2 (74 (17 to 248) μg g(-1)) and DOL 28 (4 (2 to 12) μg g(-1)) and were significantly elevated in ventilated infants on DOL 2, 7 and 14, and in ventilated infants with a hemodynamically significant PDA on DOL 2. Furthermore, urinary NT-proBNP/creatinine ratios on day 14 were higher in 14 ventilated infants who did not respond to pharmacological treatment and subsequently required surgical PDA closure (247 (214 to 547) μg g(-1)) than in ventilated infants (n=7) with successful pharmacological PDA closure (55 (21 to 114) μg g(-1); P<0.05). A cutoff >210 μg g(-1) on day 14 had a sensitivity of 75% and specificity of 100% for predicting non-responsiveness to pharmacological treatment.Conclusion:Measurement of urinary NT-proBNP is a new and simple non-invasive test for preterm infants, which may be helpful in guiding PDA treatment decisions.Journal of Perinatology advance online publication, 28 June 2012; doi:10.1038/jp.2012.86.
C Czernik; B Metze; C Müller; C Bührer
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-28
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  -     ISSN:  1476-5543     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Neonatology, Klinik für Neonatologie, Charité University Medical Center, Berlin, Germany.
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