Document Detail

Urinary NT-proBNP and ductal closure in preterm infants.
MedLine Citation:
PMID:  22743407     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To explore the association of urinary N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations and closure of patent ductus arteriosus (PDA) in preterm infants.
STUDY DESIGN: Blinded prospective study involving 136 preterm infants (median (interquartile range) gestational age 28 (26 to 30) weeks; birth weight 1030 (780 to 1270) g). NT-proBNP was determined in urine collected on day of life (DOL) 2, 7, 14 and 28.
RESULT: Urinary NT-proBNP/creatinine ratios declined continuously between DOL 2 (74 (17 to 248) μg g(-1)) and DOL 28 (4 (2 to 12) μg g(-1)) and were significantly elevated in ventilated infants on DOL 2, 7 and 14, and in ventilated infants with a hemodynamically significant PDA on DOL 2. Furthermore, urinary NT-proBNP/creatinine ratios on day 14 were higher in 14 ventilated infants who did not respond to pharmacological treatment and subsequently required surgical PDA closure (247 (214 to 547) μg g(-1)) than in ventilated infants (n=7) with successful pharmacological PDA closure (55 (21 to 114) μg g(-1); P<0.05). A cutoff >210 μg g(-1) on day 14 had a sensitivity of 75% and specificity of 100% for predicting non-responsiveness to pharmacological treatment.
CONCLUSION: Measurement of urinary NT-proBNP is a new and simple non-invasive test for preterm infants, which may be helpful in guiding PDA treatment decisions.
C Czernik; B Metze; C Müller; C Bührer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-06-28
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  33     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-27     Completed Date:  2013-08-12     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  212-7     Citation Subset:  IM    
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Biological Markers / urine
Creatine / urine
Ductus Arteriosus, Patent / drug therapy*,  ultrasonography
Echocardiography, Doppler, Color
Indomethacin / therapeutic use
Infant, Newborn
Infant, Premature
Infant, Very Low Birth Weight
Natriuretic Peptide, Brain / urine*
Peptide Fragments / urine*
Prospective Studies
Sensitivity and Specificity
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Biological Markers; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain; MU72812GK0/Creatine; XXE1CET956/Indomethacin

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