Document Detail


Urinary NT-proBNP. A valuable marker in the assessment of patients with essential hypertension.
MedLine Citation:
PMID:  19889344     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim was to evaluate the usefulness of urinary N-terminal fragment of B-type natriuretic peptide (NT-proBNP) measurement for predicting the presence of left ventricular hypertrophy (LVH) in 160 asymptomatic patients with essential hypertension. The urinary NT-proBNP/creatinine ratio was higher in patients with LVH than in either those without LVH (P< .0001) or control subjects (P< .0001). Multivariate linear regression analysis identified age (P=.034), left ventricular mass index (P=.026) and serum NT-proBNP level (P=.001) as predictors of the urinary peptide level. The area under the curve for the NT-proBNP/creatinine ratio was 0.71+/-0.04 (P< .0001) for identifying LVH. Logistic regression analysis showed that the NT-proBNP: creatinine ratio was a predictor of LVH (odds ratio=4.074; P=.009). In conclusion, the urinary NT-proBNP concentration is a new marker that could be useful for identifying LVH in subjects with essential hypertension.
Authors:
Esther Rosell?-Llet?; Miguel Rivera; Raquel Cort?s; Lilian Grigorian; Vicente Mir?; Federico Soria; Manuel Portol?s; Vicente Bertomeu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Revista espa?ola de cardiolog?a     Volume:  62     ISSN:  1579-2242     ISO Abbreviation:  Rev Esp Cardiol     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-05     Completed Date:  2010-02-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404277     Medline TA:  Rev Esp Cardiol     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  1322-5     Citation Subset:  IM    
Affiliation:
Centro de Investigaci?n del Hospital Universitario La Fe, Valencia, Spain.
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MeSH Terms
Descriptor/Qualifier:
Aged
Biological Markers / urine*
Cross-Sectional Studies
Female
Humans
Hypertension / urine*
Male
Middle Aged
Natriuretic Peptide, Brain / urine*
Peptide Fragments / urine*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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