| Urinary NT-proBNP. A valuable marker in the assessment of patients with essential hypertension. | |
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MedLine Citation:
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PMID: 19889344 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim was to evaluate the usefulness of urinary N-terminal fragment of B-type natriuretic peptide (NT-proBNP) measurement for predicting the presence of left ventricular hypertrophy (LVH) in 160 asymptomatic patients with essential hypertension. The urinary NT-proBNP/creatinine ratio was higher in patients with LVH than in either those without LVH (P< .0001) or control subjects (P< .0001). Multivariate linear regression analysis identified age (P=.034), left ventricular mass index (P=.026) and serum NT-proBNP level (P=.001) as predictors of the urinary peptide level. The area under the curve for the NT-proBNP/creatinine ratio was 0.71+/-0.04 (P< .0001) for identifying LVH. Logistic regression analysis showed that the NT-proBNP: creatinine ratio was a predictor of LVH (odds ratio=4.074; P=.009). In conclusion, the urinary NT-proBNP concentration is a new marker that could be useful for identifying LVH in subjects with essential hypertension. |
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Authors:
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Esther Rosell?-Llet?; Miguel Rivera; Raquel Cort?s; Lilian Grigorian; Vicente Mir?; Federico Soria; Manuel Portol?s; Vicente Bertomeu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Revista espa?ola de cardiolog?a Volume: 62 ISSN: 1579-2242 ISO Abbreviation: Rev Esp Cardiol Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-05 Completed Date: 2010-02-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404277 Medline TA: Rev Esp Cardiol Country: Spain |
Other Details:
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Languages: eng Pagination: 1322-5 Citation Subset: IM |
Affiliation:
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Centro de Investigaci?n del Hospital Universitario La Fe, Valencia, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biological Markers / urine* Cross-Sectional Studies Female Humans Hypertension / urine* Male Middle Aged Natriuretic Peptide, Brain / urine* Peptide Fragments / urine* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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