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Urinary NGAL at Birth Predicts Early Renal Function in Very Low Birth Weight Infants.
MedLine Citation:
PMID:  21691251     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Preterm infants are exposed to conditions that can impair renal function. We evaluated the ability of serum and urinary neutrophil gelatinase-associated lipocalin (sNGAL and uNGAL) to predict renal function in the first weeks of life. From September 2008 to July 2009, infants weighing ≤1500 g at birth with no major congenital anomalies or sepsis were eligible. We measured sNGAL and uNGAL levels at birth. To evaluate renal function, we determined changes in serum creatinine (sCreat) and estimated glomerular filtration rate (eGFR) from birth to day 21. Forty neonates (mean gestational age, 27±2 weeks) completed the study. Renal function improved in 32/40 (80%) infants (normal renal function, NRF group) (sCreat, from 0.97±0.2 to 0.53±0.13 mg/dl; eGFR, from 15.3±4.1 to 28.6±7.9 ml/min), whereas renal function worsened in 8/40 (20%) infants (impaired renal function, IRF group) (sCreat, from 0.71±0.27 to 0.98±0.43 mg/dl; eGFR from 23±14.7 to 16.4±9.1 ml/min). The uNGAL/urinary creatinine ratio at birth was higher in the IRF group (31.05 ng/mg) than the NRF group (6.0 ng/mg), and uNGAL was significantly higher in IRF group, detecting impaired renal function with a cut-off of 100 ng/ml. uNGAL levels at birth may have a predictive role in very low birth weight (VLBW) infants. ABBREVIATIONS::
Authors:
Gaetano La Manna; Silvia Galletti; Irene Capelli; Silvia Vandini; Katia Nisi; Giulia Aquilano; Rita Mancini; Elisa Carretta; Giovanni Montini; Giacomo Faldella; Sergio Stefoni
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-17
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Internal Medicine, Aging and Renal Disease [G.L.M., I.C., K.N., S.S.], Department of Woman Child and Adolescent Health [S.G., S.V., G.A., G.F.], Laboratory of Pathology and Clinical Chemistry [R.M.], Department of Pediatrics [G.M.], St. Orsola Hospital, University of Bologna, 40138 Bologna, Italy; Department of Medicine and Public Health [E.C.], University of Bologna, 40126 Bologna, Italy;
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