| Urinary N-acetyl-beta-D-glucosaminidase (NAG) activity in patients with Graves' disease, subacute thyroiditis, and silent thyroiditis: a longitudinal study. | |
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MedLine Citation:
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PMID: 1794337 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Urinary N-acetyl-beta-D-glucosaminidase (NAG) activity was measured longitudinally in 12 patients with Graves' disease, 5 patients with subacute thyroiditis, and 1 patient with silent thyroiditis, and compared with that of 36 normal controls. The patients with Graves' disease and subacute thyroiditis were treated with anti-thyroid drug (methimazole or propylthiouracil) and prednisolone, respectively. On the other hand, no treatment was given to the patient with silent thyroiditis. Since two patients with Graves' disease clearly showed transient deterioration of the thyroid function during the treatment period, data from these two patients were separately investigated. Urinary levels of NAG in the remaining ten patients with Graves' disease before, 1, 3, 6 and 12 months after the treatment were 15.59 +/- 7.93 (SD), 8.96 +/- 6.82, 4.39 +/- 2.33, 3.46 +/- 2.24, and 3.63 +/- 2.38 U/g.creatinine (g.Cr.), respectively. Those obtained before, 1 and 3 months after the treatment were significantly higher than those of the controls (2.85 +/- 1.12 U/g.Cr.). Free thyroid hormone levels became normal or low 3 months after the treatment. The two Graves' patients mentioned above showed a transient increase in urinary NAG with concomitant changes in free thyroid hormone levels. Urinary NAG levels in the patients with subacute thyroiditis before, 2, 4, and 6 weeks after the treatment were 16.56 +/- 10.97, 6.76 +/- 2.79, 3.14 +/- 0.48 and 3.70 +/- 1.44 U/g.Cr., respectively. Those obtained before and 2 weeks after the treatment were significantly higher than those of the controls. Free thyroid hormones were normal 2 weeks after therapy. Urinary NAG in the patient with silent thyroiditis was 9.60 U/g.Cr. on the first visit and gradually decreased.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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S Nakamura; M Ishiyama; J Kosaka; J Mutoh; N Umemura; C Harase |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Endocrinologia japonica Volume: 38 ISSN: 0013-7219 ISO Abbreviation: Endocrinol. Jpn. Publication Date: 1991 Jun |
Date Detail:
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Created Date: 1992-04-08 Completed Date: 1992-04-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376546 Medline TA: Endocrinol Jpn Country: JAPAN |
Other Details:
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Languages: eng Pagination: 303-8 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Gifu Red Cross Hospital, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylglucosaminidase
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urine* Adolescent Adult Child Female Graves Disease / enzymology* Humans Longitudinal Studies Male Middle Aged Thyroiditis / enzymology* Thyroiditis, Subacute / enzymology* |
| Chemical | |
Reg. No./Substance:
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EC 3.2.1.52/Acetylglucosaminidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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