Document Detail


Urinary N-acetyl-beta-D-glucosaminidase (NAG) activity in patients with Graves' disease, subacute thyroiditis, and silent thyroiditis: a longitudinal study.
MedLine Citation:
PMID:  1794337     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Urinary N-acetyl-beta-D-glucosaminidase (NAG) activity was measured longitudinally in 12 patients with Graves' disease, 5 patients with subacute thyroiditis, and 1 patient with silent thyroiditis, and compared with that of 36 normal controls. The patients with Graves' disease and subacute thyroiditis were treated with anti-thyroid drug (methimazole or propylthiouracil) and prednisolone, respectively. On the other hand, no treatment was given to the patient with silent thyroiditis. Since two patients with Graves' disease clearly showed transient deterioration of the thyroid function during the treatment period, data from these two patients were separately investigated. Urinary levels of NAG in the remaining ten patients with Graves' disease before, 1, 3, 6 and 12 months after the treatment were 15.59 +/- 7.93 (SD), 8.96 +/- 6.82, 4.39 +/- 2.33, 3.46 +/- 2.24, and 3.63 +/- 2.38 U/g.creatinine (g.Cr.), respectively. Those obtained before, 1 and 3 months after the treatment were significantly higher than those of the controls (2.85 +/- 1.12 U/g.Cr.). Free thyroid hormone levels became normal or low 3 months after the treatment. The two Graves' patients mentioned above showed a transient increase in urinary NAG with concomitant changes in free thyroid hormone levels. Urinary NAG levels in the patients with subacute thyroiditis before, 2, 4, and 6 weeks after the treatment were 16.56 +/- 10.97, 6.76 +/- 2.79, 3.14 +/- 0.48 and 3.70 +/- 1.44 U/g.Cr., respectively. Those obtained before and 2 weeks after the treatment were significantly higher than those of the controls. Free thyroid hormones were normal 2 weeks after therapy. Urinary NAG in the patient with silent thyroiditis was 9.60 U/g.Cr. on the first visit and gradually decreased.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
S Nakamura; M Ishiyama; J Kosaka; J Mutoh; N Umemura; C Harase
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endocrinologia japonica     Volume:  38     ISSN:  0013-7219     ISO Abbreviation:  Endocrinol. Jpn.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1992-04-08     Completed Date:  1992-04-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376546     Medline TA:  Endocrinol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  303-8     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Gifu Red Cross Hospital, Japan.
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MeSH Terms
Descriptor/Qualifier:
Acetylglucosaminidase / urine*
Adolescent
Adult
Child
Female
Graves Disease / enzymology*
Humans
Longitudinal Studies
Male
Middle Aged
Thyroiditis / enzymology*
Thyroiditis, Subacute / enzymology*
Chemical
Reg. No./Substance:
EC 3.2.1.52/Acetylglucosaminidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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