| Urinary inositol phosphoglycan P-type as a marker for prediction of preeclampsia and novel implications for the pathophysiology of this disorder. | |
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MedLine Citation:
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PMID: 20701477 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Hypertensive disorders represent the most common complications of human pregnancy with substantial impact on fetal and maternal outcomes. Inositol phosphoglycan P-type has recently been identified as a novel marker of preeclampsia, the most severe form of hypertension during pregnancy, with a significant increase in urinary excretion preceding the clinical diagnosis. METHODS: A prospective, longitudinal study was carried out to assess the potential of urinary levels of inositol phosphoglycan P-type as a screening test for preeclampsia. A specific ELISA-based test was used to assess urinary levels of P-IPG. RESULTS: Nine patients out of 93 women recruited (496 urinary samples were collected) went on to develop preeclampsia in a cohort of women with high-risk pregnancies. A cut-off value of urinary inositol phosphoglycan P-type was identified by ROC analysis providing a sensitivity and specificity for the current protocol of 88.9% and 62.7%, respectively. Twenty-three women with healthy pregnancies had sporadic episodes of increased excretion of inositol phosphoglycan P-type during pregnancy that consistently resolved back to normal baseline without development of preeclampsia. There was no correlation of urine levels of inositol phosphoglycan P-type and urine protein and patients with gestational hypertension had normal levels of urine inositol phosphoglycan P-type. CONCLUSIONS: These findings suggest that, given the rapid raise of P-IPG before the onset of the disease, multiple assessments may help at identifying women at risk of developing preeclampsia. |
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Authors:
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Malcolm A Paine; Marco Scioscia; Philip J Williams; Khalid Gumaa; Charles H Rodeck; Thomas W Rademacher |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy Volume: 29 ISSN: 1525-6065 ISO Abbreviation: Hypertens Pregnancy Publication Date: 2010 |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2011-01-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421297 Medline TA: Hypertens Pregnancy Country: England |
Other Details:
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Languages: eng Pagination: 375-84 Citation Subset: IM |
Affiliation:
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Department of Immunology and Molecular Pathology, Molecular Medicine Unit, Royal Free and University College London Medical School, London, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Biological Markers / urine Enzyme-Linked Immunosorbent Assay Female Humans Inositol Phosphates / urine* Polysaccharides / urine* Pre-Eclampsia / urine* Predictive Value of Tests Pregnancy Pregnancy, High-Risk / urine* Prospective Studies ROC Curve Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Inositol Phosphates; 0/Polysaccharides; 0/inositol phosphate glycan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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