Document Detail


Urinary Incontinence, Hyperthermia, and Sudden Death.
MedLine Citation:
PMID:  21470226     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
  An 84-year-old woman is reported whose death was associated with strenuous exercise on an extremely hot day (maximum temperature = 43.1°C, 109.6°F). At autopsy there was evidence of exposure to high environmental temperatures with early putrefactive changes and mummification. There was underlying cardiomegaly with mild pulmonary emphysema. No significant injuries were detected. Toxicology revealed therapeutic levels of oxybutynin prescribed for urinary stress incontinence. Death was considered to be heat related, exacerbated by oxybutynin therapy, exercise, and cardiomegaly. Given that it has been predicted that there may be an increase in the number of heatwaves and in their intensity and duration, it is possible that such cases may be encountered more often in future. The assessment of all deaths occurring during conditions of extreme heat will require consideration of postmortem toxicology, particularly if there are underlying conditions such as stress incontinence that may be associated with anticholinergic drug therapy.
Authors:
Jonathon Herbst; John D Gilbert; Roger W Byard
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-6
Journal Detail:
Title:  Journal of forensic sciences     Volume:  -     ISSN:  1556-4029     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375370     Medline TA:  J Forensic Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 American Academy of Forensic Sciences.
Affiliation:
Forensic Science SA, 21 Divett Place, Adelaide, SA 5000, Australia. Discipline of Pathology, The University of Adelaide, Frome Road, Adelaide, SA 5005, Australia.
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