| Urinary Erythropoietin Concentrations after Early Short-Term Infusion of High-Dose Recombinant Epo for Neuroprotection in Preterm Neonates. | |
| | |
MedLine Citation:
|
PMID: 22776958 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background: High-dose recombinant human erythropoietin (rEpo) has first been administered in clinical trials for neuroprotection in very preterm neonates at high risk of brain injury and in (near-) term neonates with hypoxic-ischemic encephalopathy. However, recent trials in adults raised concerns about the safety of high-dose rEpo for neuro- and cardioprotection. Objectives: To evaluate the putative accumulation or renal leakage of Epo as a function of developmental stage after repetitive early short-term infusion of high-dose rEpo (3 × 3,000 U/kg within 42 h after birth; NCT00413946) for neuroprotection in very preterm infants. Methods: Epo concentrations were measured using the ELISA technique in the first two consecutive urine specimens after each rEpo infusion. Results: Renal Epo excretion was significantly higher in preterm infants with gestational ages <29 weeks than in more mature infants and reached up to 23% of the administered rEpo within 8 h after each infusion. The urinary Epo concentration did not increase after three repetitive infusions of high-dose rEpo. The ratio of urinary Epo to total protein concentrations was the same in infants with gestational ages <29 weeks and in those with gestational ages ≥29 weeks. Conclusions: Our data suggest that the higher renal Epo excretion in more immature infants may be attributed to a higher glomerular filtration leakage due to the lower maturation of the kidneys and argue against saturation kinetics after multiple doses of 3,000 U/kg rEpo. This information should be considered in future trials on the use of rEpo for neuroprotection in neonates. |
| | |
Authors:
|
Christof Dame; Juliane Langer; Brigitte M Koller; Jean-Claude Fauchère; Hans Ulrich Bucher |
Related Documents
:
|
21393308 - Meta-analysis of the association between preterm delivery and intelligence. 7296178 - Identity alterations and prognosis in schizophrenia. 16194978 - Season of birth distribution of elite tennis players. 18194088 - Epidemiologic characterization of the 1918 influenza pandemic summer wave in copenhagen... 8244788 - Delirium tremens: a review. 1883648 - Three cases of congenital adrenal hypoplasia: a cause of salt-wasting and mortality in ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-7-04 |
Journal Detail:
|
Title: Neonatology Volume: 102 ISSN: 1661-7819 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
|
Created Date: 2012-7-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101286577 Medline TA: Neonatology Country: - |
Other Details:
|
Languages: ENG Pagination: 172-177 Citation Subset: - |
Copyright Information:
|
Copyright © 2012 S. Karger AG, Basel. |
Affiliation:
|
Department of Neonatology, Charité - Universitätsmedizin Berlin, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: High-performance liquid chromatographic analysis of as-synthesised N,N'-dimethylformamide-stabilised...
Next Document: Retargeting sleeping beauty transposon insertions by engineered zinc finger DNA-binding domains.