Document Detail


Urinary DEHP metabolites and fasting time in NHANES.
MedLine Citation:
PMID:  21847144     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exposure assessment analyses conducted in Europe have concluded that the primary pathway of exposure to di(2-ethylhexyl) phthalate (DEHP) is through the diet. The purpose of this study is to evaluate whether urinary DEHP metabolite data from the 2007-2008 National Health and Nutritional Examination Survey (NHANES) demonstrate relationships with reported food-fasting time consistent with diet as the predominant exposure pathway. Previous controlled-dosing data demonstrate that DEHP metabolite concentrations in urine first rise and then decline over time, with first-order elimination becoming evident at about 6 h post exposure. Regression of the concentrations of four key DEHP metabolites vs reported fasting times between 6 and 18 h in adults resulted in apparent population-based urinary elimination half-lives, consistent with those previously determined in a controlled-dosing experiment, supporting the importance of the dietary pathway for DEHP. For fasting times less than about 6 h, sampling session (morning, afternoon, or evening) affected the measured metabolite concentrations. Evening samples showed the highest metabolite concentrations, supporting a hypothesis of recent daily dietary exposures from multiple meals, whereas morning and afternoon samples for fasting times less than 6 h were similar and somewhat lower than evening samples, consistent with less-substantial early day dietary exposure. Variations in children's bodyweight-normalized creatinine excretion and food intake rates contribute to a strong inverse relationship between urinary DEHP metabolite concentrations and age under age 18. Finally, a previously published pharmacokinetic model for DEHP demonstrates that time since previous urinary void, a parameter not measured in NHANES, is predicted to result in non-random effects on measured urinary concentrations.
Authors:
Lesa L Aylward; Matthew Lorber; Sean M Hays
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-08-17
Journal Detail:
Title:  Journal of exposure science & environmental epidemiology     Volume:  21     ISSN:  1559-064X     ISO Abbreviation:  J Expo Sci Environ Epidemiol     Publication Date:    2011 Nov-Dec
Date Detail:
Created Date:  2011-10-20     Completed Date:  2012-02-15     Revised Date:  2012-03-26    
Medline Journal Info:
Nlm Unique ID:  101262796     Medline TA:  J Expo Sci Environ Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  615-24     Citation Subset:  IM    
Affiliation:
Summit Toxicology, LLP, Falls Church, Virginia 22044, USA. laylward@summittoxicology.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Diethylhexyl Phthalate / pharmacokinetics,  toxicity,  urine*
Environmental Exposure / analysis*,  statistics & numerical data
Female
Humans
Male
Nutrition Surveys
Plasticizers / analysis*,  pharmacokinetics,  toxicity
Risk Assessment / methods,  statistics & numerical data
Time Factors
United States / epidemiology
Chemical
Reg. No./Substance:
0/Plasticizers; 117-81-7/Diethylhexyl Phthalate

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