Document Detail

Urinary CXCL9 and CXCL10 levels correlate with the extent of subclinical tubulitis.
MedLine Citation:
PMID:  19459809     Owner:  NLM     Status:  MEDLINE    
Subclinical tubulitis has been associated with the later development of interstitial fibrosis and tubular atrophy (IF/TA), leading to diminished allograft survival. The aim of this study was to investigate how concentrations of urinary CXC-receptor 3 (CXCR3) chemokines (i.e. CXCL4/9/10/11) and CCL2 relate to the extent of subclinical tubulitis. Using ELISA, urinary CXCR3 chemokines, CCL2 and tubular injury markers (i.e. urinary NGAL and alpha1-microglobulin [alpha1 m]) were measured in patients with stable estimated GFR >or=40 mL/min exhibiting normal tubular histology (n = 24), subclinical borderline tubulitis (n = 18) or subclinical tubulitis Ia/Ib (n = 22), as well as in patients with clinical tubulitis Ia/Ib (n = 17) or IF/TA (n = 10). CXCL9 and CXCL10 were significantly higher in subclinical tubulitis Ia/Ib than in subclinical borderline tubulitis (p <or= 0.03) and normal tubular histology (p <or= 0.0002). By contrast, NGAL, alpha1-m, CXCL4, CXCL11 and CCL2 were not or only marginally distinctive across these patient groups. All urinary chemokines and tubular injury markers were higher in clinical tubulitis Ia/Ib than in normal tubular histology (p <or= 0.002), but only tubular injury markers were elevated in IF/TA. These results demonstrate a correlation of urinary CXCL9 and CXCL10 levels with the extent of subclinical tubulitis suggesting potential as noninvasive screening biomarkers.
S Schaub; P Nickerson; D Rush; M Mayr; C Hess; M Golian; W Stefura; K Hayglass
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-13
Journal Detail:
Title:  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons     Volume:  9     ISSN:  1600-6143     ISO Abbreviation:  Am. J. Transplant.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-08-06     Completed Date:  2009-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100968638     Medline TA:  Am J Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1347-53     Citation Subset:  IM    
Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland.
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MeSH Terms
Acute-Phase Proteins / urine
Alpha-Globulins / urine
Biological Markers / urine
Chemokine CXCL10 / urine*
Chemokine CXCL9 / urine*
Graft Rejection / urine*
Kidney Transplantation / adverse effects*,  pathology
Kidney Tubules / pathology
Lipocalins / urine
Middle Aged
Proto-Oncogene Proteins / urine
Pyelonephritis / pathology,  urine*
Receptors, CXCR3
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Alpha-Globulins; 0/Biological Markers; 0/Chemokine CXCL10; 0/Chemokine CXCL9; 0/LCN2 protein, human; 0/Lipocalins; 0/Proto-Oncogene Proteins; 0/Receptors, CXCR3; 0/alpha-1-microglobulin

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