Document Detail

Urinary BLCA-4 Level is Useful to Detect Upper Urinary Tract Urothelial Cell Carcinoma.
MedLine Citation:
PMID:  22998857     Owner:  NLM     Status:  Publisher    
OBJECTIVE: Upper urinary tract urothelial cell carcinomas (UUT-UCCs) are rare but usually invasive at diagnosis. Early diagnosis of UUT-UCCs is thus warranted. UUT has the same embryological origin with bladder and BLCA-4 is a highly sensitive and specific marker for bladder cancer. We intend to investigate the viability of BLCA-4 in detecting UUT-UCCs. MATERIAL AND METHODS: Urines from 30 UUT-UCC patients, 10 ureteral polyp patients, 20 infected patients with incarcerated ureteral stones, and 30 normal controls were included. BLCA-4 antibody was produced and applied in an indirect ELISA assay. RESULTS: Urinary BLCA-4 is significantly higher in UUT-UCC group than «Polyp» group (P=0.0017), «Infection» group (P<0.0001), or « Normal» group (P<0.0001). The «Polyp» group is also higher than «Infection» group (P=0.015), or «Normal» group (P=0.0009). ROC curve revealed at cut-off of 5.5×10(-4)A, sensitivity was 93.3% and specificity was 100%. When grouped as ureteral mass vs normal, same cut-off value yielded 93.3% sensitivity and 83.3% specificity. At 2.4×10(-4)A, sensitivity was 56.7% and specificity was 97.2%. CONCLUSIONS: Urinary BLCA-4 is also highly specific in UUT-UCCs detection. For incidentally identified ureteral mass, BLCA-4 can be considered an auxiliary indicator besides biopsy.
C-C Feng; Z Wu; H-W Jiang; H Wen; M Guan; Q Ding
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-18
Journal Detail:
Title:  Actas urologicas espanolas     Volume:  -     ISSN:  1699-7980     ISO Abbreviation:  Actas Urol Esp     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704993     Medline TA:  Actas Urol Esp     Country:  -    
Other Details:
Languages:  ENG; SPA     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 AEU. Published by Elsevier Espana. All rights reserved.
Servicio de Urología, Hospital Huashan, Universidad Fudan, Shanghai, China. Electronic address:
Vernacular Title:
El nivel de BLCA-4 urinario es útil para la detección del carcinoma de células uroteliales de vía urinaria superior.
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