Document Detail


Urinary angiotensinogen accurately reflects intrarenal Renin-Angiotensin system activity.
MedLine Citation:
PMID:  20160435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: We recently reported that immunoreactivity of intrarenal angiotensinogen (AGT) is significantly increased in IgA nephropathy patients. Meanwhile, we have developed direct enzyme-linked immunosorbent assays to measure plasma and urinary AGT (UAGT) in humans. This study was performed to test the hypothesis that UAGT levels are increased in chronic glomerulonephritis patients.
METHODS: We analyzed 100 urine samples from 70 chronic glomerulonephritis patients (26 from IgA nephropathy, 24 from purpura nephritis, 8 from lupus nephritis, 7 from focal segmental glomerulosclerosis, and 5 from non-IgA mesangial proliferative glomerulonephritis) and 30 normal control subjects.
RESULTS: UAGT-creatinine ratio (UAGT/UCre) was correlated positively with diastolic blood pressure (p = 0.0326), urinary albumin-creatinine ratio (p < 0.0001), urinary protein-creatinine ratio (p < 0.0001) and urinary occult blood (p = 0.0094). UAGT/UCre was significantly increased in chronic glomerulonephritis patients not treated with renin-angiotensin system (RAS) blockers compared with control subjects (p < 0.0001). Importantly, glomerulonephritis patients treated with RAS blockers had a marked attenuation of this augmentation (p = 0.0021).
CONCLUSION: These data indicate that UAGT are increased in chronic glomerulonephritis patients and treatment with RAS blockers suppressed UAGT. The efficacy of RAS blockade to reduce the intrarenal RAS activity can be confirmed by measurement of UAGT in chronic glomerulonephritis patients.
Authors:
Maki Urushihara; Shuji Kondo; Shoji Kagami; Hiroyuki Kobori
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-02-15
Journal Detail:
Title:  American journal of nephrology     Volume:  31     ISSN:  1421-9670     ISO Abbreviation:  Am. J. Nephrol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-14     Completed Date:  2010-08-16     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  8109361     Medline TA:  Am J Nephrol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  318-25     Citation Subset:  IM    
Copyright Information:
2010 S. Karger AG, Basel.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Angiotensinogen / urine*
Child
Child, Preschool
Female
Glomerulonephritis / physiopathology,  urine*
Humans
Kidney / physiopathology
Male
Renin-Angiotensin System / physiology*
Reproducibility of Results
Young Adult
Grant Support
ID/Acronym/Agency:
P20RR017659/RR/NCRR NIH HHS; R01 DK072408/DK/NIDDK NIH HHS; R01DK072408/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
11002-13-4/Angiotensinogen
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