Document Detail


Urinary 8-isoprostaglandin F(2alpha) level in Behçet's disease.
MedLine Citation:
PMID:  16303608     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although its etiology remains unknown, the increased production of reactive oxygen species in Behçet's disease (BD) have been reported. Furthermore, it has been suggested that vascular and endothelial tissue damage seen in BD is related to elevated reactive oxygen species generated by activated neutrophils from BD patients. To investigate the formation of lipid peroxidation in BD patients in vivo, urinary level of 8-isoprostaglandin F(2alpha) was quantitated by enzyme immunoassay after solid phase extraction in different clinical forms of BD patients. There was no difference in urinary level of 8-isoprostaglandin F(2alpha) between BD patient and healthy control group. There was also no difference in urinary levels of 8-isoprostaglandin F(2alpha) in subgroup analyses of BD patients, i.e. in mucocutaneous and vascular type BD patients; active and inactive BD patients. Contrary to the findings in literature, we found no difference in urinary level of 8-isoprostaglandin F(2alpha) between patients with systemic lupus erythematosus and healthy control group. These findings show no increase in lipid peroxidation despite the augmented formation of reactive oxygen species in BD patients. It may be interesting to assess formation of urinary level of 8-isoprostaglandin F(2alpha) in BD patients who do not take any medication.
Authors:
Nalan Ciçek Ozdöl; Aşkin Ateş; Olcay Tiryaki Aydintuğ; Mehmet Melli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins & other lipid mediators     Volume:  78     ISSN:  1098-8823     ISO Abbreviation:  Prostaglandins Other Lipid Mediat.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-23     Completed Date:  2006-04-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9808648     Medline TA:  Prostaglandins Other Lipid Mediat     Country:  United States    
Other Details:
Languages:  eng     Pagination:  96-106     Citation Subset:  IM    
Affiliation:
Ankara University, School of Medicine, Department of Pharmacology and Clinical Pharmacology, Morfoloji Binasi, Sihhiye 06100, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adult
Behcet Syndrome / classification,  urine*
Case-Control Studies
Female
Humans
Immunoenzyme Techniques
Male
Middle Aged
Prostaglandins A / urine*
Chemical
Reg. No./Substance:
0/8-isoprostaglandin A2; 0/Prostaglandins A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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