Document Detail


Urinary 8-hydroxydeoxyguanosine in infants and children.
MedLine Citation:
PMID:  9684987     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several diseases of prematurity are thought to be related to oxidative injury and many of the available markers are unsatisfactory. An assay was developed using HPLC with electrochemical detection for the quantitation of urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) as a proposed indicator for oxygen-derived free radical injury to DNA in preterm infants. A median value of 3.79 micromol/mol creatinine was obtained for normal children (2-15 years old, n=14). Urinary 8-OHdG excretion in neonates ranged from 0-99 micromol/mol creatinine. There were no gestation or birthweight related differences in urinary 8-OHdG, and no correlation with urinary malondialdehyde. Mean 8-OHdG excretion increased with postnatal age (r=0.80, p < 0.0001, n=15), mirroring the growth velocity curve. These changes could also be due to changes in the activity of the enzyme responsible for 8-OHdG excision. Urinary 8-OHdG levels are unlikely to accurately reflect oxygen derived free radical activity given the strength of the relationship with growth.
Authors:
J A Drury; G Jeffers; R W Cooke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Free radical research     Volume:  28     ISSN:  1071-5762     ISO Abbreviation:  Free Radic. Res.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-10-19     Completed Date:  1998-10-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  423-8     Citation Subset:  IM    
Affiliation:
Department of Child Health, University of Liverpool, Alder Hey Children's Hospital, England. jadrury@liverpool.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Birth Weight
Child, Preschool
Deoxyguanosine / analogs & derivatives*,  urine
Female
Gestational Age
Humans
Infant, Newborn
Infant, Premature*
Lipid Peroxidation
Male
Malondialdehyde / urine
Nephrotic Syndrome / therapy,  urine
Reference Values
Sex Factors
Chemical
Reg. No./Substance:
0/8-hydroxy-2'-deoxyguanosine; 542-78-9/Malondialdehyde; 961-07-9/Deoxyguanosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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