Document Detail


Urinary 8-hydroxy-2'-deoxyguanosine reflects symptomatic status and severity of systolic dysfunction in patients with chronic heart failure.
MedLine Citation:
PMID:  20965876     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: Oxidative stress is known to play a crucial role in the pathogenesis of heart failure (HF). We investigated whether urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), a product of oxidative DNA damage, is a clinically useful biomarker of the severity of chronic heart failure (CHF) and oxidative stress levels in failing hearts.
METHODS AND RESULTS: We measured 8-OHdG in the serum obtained from the coronary sinus (CS) and aortic root (Ao) in small groups of control subjects and CHF patients. We then measured urinary 8-OHdG and other biomarkers (brain natriuretic peptide, 8-isoplastane, high-sensitivity C-reactive protein, interleukin-6, and tumour necrosis factor-α) in 31 control subjects and 194 patients with CHF [left-ventricular ejection fraction (LVEF): 28.3 ± 8.1%]. Serum 8-OHdG was significantly higher in the CS than the Ao in CHF patients only. Urinary 8-OHdG was also significantly higher in CHF patients than in control subjects, and urinary 8-OHdG became higher as New York Heart Association class increased. Moreover, there was a significant correlation between urinary 8-OHdG and LVEF (r = -0.27), pulmonary capillary wedge pressure (r = 0.31), or left-ventricular end-diastolic volume index (r = 0.22). In contrast, there was poor correlation between the severity of CHF and the other neurohumoral biomarkers.
CONCLUSION: In HF, urinary 8-OHdG seems to reflect the level of oxidative stress and various parameters related to symptomatic status and functional severity of CHF.
Authors:
Shigeki Kobayashi; Takehisa Susa; Takeo Tanaka; Yasuaki Wada; Shinichi Okuda; Masahiro Doi; Tomoko Nao; Yasuhiro Yoshiga; Jutaro Yamada; Takayuki Okamura; Takeshi Ueyama; Syuji Kawamura; Masafumi Yano; Masunori Matsuzaki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-20
Journal Detail:
Title:  European journal of heart failure     Volume:  13     ISSN:  1879-0844     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  2011-04-05     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  29-36     Citation Subset:  IM    
Affiliation:
Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan. skoba@yamaguchi-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aorta
Biological Markers / blood,  urine
Case-Control Studies
Coronary Sinus
Deoxyguanosine / analogs & derivatives*,  blood,  urine
Disease Progression
Female
Heart Failure, Systolic / blood,  pathology,  urine*
Humans
Linear Models
Male
Middle Aged
Multivariate Analysis
Oxidative Stress / physiology
Prognosis
Reactive Oxygen Species
Severity of Illness Index
Stroke Volume
Ventricular Function, Left
Chemical
Reg. No./Substance:
0/8-hydroxy-2'-deoxyguanosine; 0/Biological Markers; 0/Reactive Oxygen Species; 961-07-9/Deoxyguanosine

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