| Urinary 8-hydroxy-2'-deoxyguanosine reflects symptomatic status and severity of systolic dysfunction in patients with chronic heart failure. | |
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MedLine Citation:
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PMID: 20965876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Oxidative stress is known to play a crucial role in the pathogenesis of heart failure (HF). We investigated whether urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), a product of oxidative DNA damage, is a clinically useful biomarker of the severity of chronic heart failure (CHF) and oxidative stress levels in failing hearts. METHODS AND RESULTS: We measured 8-OHdG in the serum obtained from the coronary sinus (CS) and aortic root (Ao) in small groups of control subjects and CHF patients. We then measured urinary 8-OHdG and other biomarkers (brain natriuretic peptide, 8-isoplastane, high-sensitivity C-reactive protein, interleukin-6, and tumour necrosis factor-α) in 31 control subjects and 194 patients with CHF [left-ventricular ejection fraction (LVEF): 28.3 ± 8.1%]. Serum 8-OHdG was significantly higher in the CS than the Ao in CHF patients only. Urinary 8-OHdG was also significantly higher in CHF patients than in control subjects, and urinary 8-OHdG became higher as New York Heart Association class increased. Moreover, there was a significant correlation between urinary 8-OHdG and LVEF (r = -0.27), pulmonary capillary wedge pressure (r = 0.31), or left-ventricular end-diastolic volume index (r = 0.22). In contrast, there was poor correlation between the severity of CHF and the other neurohumoral biomarkers. CONCLUSION: In HF, urinary 8-OHdG seems to reflect the level of oxidative stress and various parameters related to symptomatic status and functional severity of CHF. |
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Authors:
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Shigeki Kobayashi; Takehisa Susa; Takeo Tanaka; Yasuaki Wada; Shinichi Okuda; Masahiro Doi; Tomoko Nao; Yasuhiro Yoshiga; Jutaro Yamada; Takayuki Okamura; Takeshi Ueyama; Syuji Kawamura; Masafumi Yano; Masunori Matsuzaki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-20 |
Journal Detail:
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Title: European journal of heart failure Volume: 13 ISSN: 1879-0844 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-20 Completed Date: 2011-04-05 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 29-36 Citation Subset: IM |
Affiliation:
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Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan. skoba@yamaguchi-u.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aorta Biological Markers / blood, urine Case-Control Studies Coronary Sinus Deoxyguanosine / analogs & derivatives*, blood, urine Disease Progression Female Heart Failure, Systolic / blood, pathology, urine* Humans Linear Models Male Middle Aged Multivariate Analysis Oxidative Stress / physiology Prognosis Reactive Oxygen Species Severity of Illness Index Stroke Volume Ventricular Function, Left |
| Chemical | |
Reg. No./Substance:
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0/8-hydroxy-2'-deoxyguanosine; 0/Biological Markers; 0/Reactive Oxygen Species; 961-07-9/Deoxyguanosine |
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