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Urinary 8-OHdG: A marker of oxidative stress to DNA and total antioxidant status in essential hypertension with South Indian population.
MedLine Citation:
PMID:  23105898     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Establishment of non-invasive urinary biomarker for the early prediction of essential hypertension (EH) is important. We evaluated whether estimation of urinary DNA, serves as a marker to predict the extent of cellular oxidative stress in essential hypertension. A total of 180 South Indian subjects aged 30-65 were recruited for the study. Of these hypertensive subjects investigated, 30 were newly diagnosed and were not on any antihypertensive drugs, but had systolic blood pressure 140-160 mmHg and diastolic blood pressure 95-100 mmHg and 75 hypertensive patients who already on drug therapy for one year and 75 were South Indian normotensive healthy controls with blood pressure ≤ 120/80 mmHg. The 8-OHdG level in urine was significantly increased in hypertensive patients (both newly diagnosed and who already on drug therapy) compared with control group. The significant increase in 8-OHdG was observed in newly diagnosed hypertensive patients compared with hypertensive patients who already on drug therapy. There was a significant decrease in serum TAS value in essential hypertensive group when compared to control group. The urinary 8-OHdG was independently correlated with serum TAS. Decreased TAS levels, which reflect to increased oxidative stress, may be the reason of increased urinary 8-OHdG in South Indian hypertensive patients. Our preliminary data suggest that the competitive ELISA for 8-OHdG appears to be a simple method for quantifying the extent of oxidative stress.
Authors:
P Subash; Prema Gurumurthy; A Sarasabharathi; K M Cherian
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Publication Detail:
Type:  Journal Article     Date:  2010-05-27
Journal Detail:
Title:  Indian journal of clinical biochemistry : IJCB     Volume:  25     ISSN:  0970-1915     ISO Abbreviation:  Indian J Clin Biochem     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2012-10-29     Completed Date:  2012-10-30     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  8708303     Medline TA:  Indian J Clin Biochem     Country:  India    
Other Details:
Languages:  eng     Pagination:  127-32     Citation Subset:  -    
Affiliation:
Department of Biochemistry, Dr K.M Cherian Heart Foundation (A unit of Frontier Life Line Pvt Ltd), Mogappair, Chennai, 101 India.
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