| Urinary 8-OHdG: A marker of oxidative stress to DNA and total antioxidant status in essential hypertension with South Indian population. | |
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MedLine Citation:
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PMID: 23105898 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Establishment of non-invasive urinary biomarker for the early prediction of essential hypertension (EH) is important. We evaluated whether estimation of urinary DNA, serves as a marker to predict the extent of cellular oxidative stress in essential hypertension. A total of 180 South Indian subjects aged 30-65 were recruited for the study. Of these hypertensive subjects investigated, 30 were newly diagnosed and were not on any antihypertensive drugs, but had systolic blood pressure 140-160 mmHg and diastolic blood pressure 95-100 mmHg and 75 hypertensive patients who already on drug therapy for one year and 75 were South Indian normotensive healthy controls with blood pressure ≤ 120/80 mmHg. The 8-OHdG level in urine was significantly increased in hypertensive patients (both newly diagnosed and who already on drug therapy) compared with control group. The significant increase in 8-OHdG was observed in newly diagnosed hypertensive patients compared with hypertensive patients who already on drug therapy. There was a significant decrease in serum TAS value in essential hypertensive group when compared to control group. The urinary 8-OHdG was independently correlated with serum TAS. Decreased TAS levels, which reflect to increased oxidative stress, may be the reason of increased urinary 8-OHdG in South Indian hypertensive patients. Our preliminary data suggest that the competitive ELISA for 8-OHdG appears to be a simple method for quantifying the extent of oxidative stress. |
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Authors:
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P Subash; Prema Gurumurthy; A Sarasabharathi; K M Cherian |
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Publication Detail:
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Type: Journal Article Date: 2010-05-27 |
Journal Detail:
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Title: Indian journal of clinical biochemistry : IJCB Volume: 25 ISSN: 0970-1915 ISO Abbreviation: Indian J Clin Biochem Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2012-10-29 Completed Date: 2012-10-30 Revised Date: 2013-04-02 |
Medline Journal Info:
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Nlm Unique ID: 8708303 Medline TA: Indian J Clin Biochem Country: India |
Other Details:
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Languages: eng Pagination: 127-32 Citation Subset: - |
Affiliation:
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Department of Biochemistry, Dr K.M Cherian Heart Foundation (A unit of Frontier Life Line Pvt Ltd), Mogappair, Chennai, 101 India. |
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