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Urinary 5-HIAA excretion is not increased in patients with head and neck paragangliomas.
MedLine Citation:
PMID:  22653742     Owner:  NLM     Status:  Publisher    
Background: Case reports have documented carcinoid-like features in head and neck paragangliomas (HNPGLs), which, in addition to catecholamine storing granules, may also contain granules with serotonin. Serotonin is metabolized to 5-hydroxyindoleacetic acid (5-HIAA). ?Aim: To assess the urinary excretion rates of 5-HIAA and catecholamines in HNPGL patients.?Methods: In 114 consecutive HNPGL patients, normetanephrine, metanephrine, norepinephrine, epinephrine, VMA, dopamine, 3-methoxytyramine and 5-HIAA excretion rates were measured in two 24-hour urinary samples. Increased excretion rates were defined as an increase of the average hormone excretion rate of 2 urine samples above the reference range. In all patients with catecholamine excess, intrathoracic and abdominal paragangliomas were excluded by 123I-MIBG scintigraphy, MRI and/or CT. Genetic screening for mutations in genes of the succinate dehydrogenase (SDH) family was performed. ?Results: Mean urinary 5-HIAA excretion rate was 14±9 µmol/24 hours (reference range 10-44 µmol/24 hours). Urinary 5-HIAA excretion was slightly increased in only 1 patient (48 µmol/24 hours). None of the 50 patients (44%) with increased urinary excretion rates of catecholamines and/or their metabolites had elevated 5-HIAA excretion.?Conclusion: Urinary 5-HIAA excretion is within the normal reference range in almost all HNPGL patients. Therefore, this parameter has no clinical relevance in the routine clinical assessment of HNPGL patients.
Leonie T van Hulsteijn; Nicolette van Duinen; Johannes A Romijn; Johannes W A Smit; Eleonora P M Corssmit
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-29
Journal Detail:
Title:  The International journal of biological markers     Volume:  -     ISSN:  1724-6008     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-6-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8712411     Medline TA:  Int J Biol Markers     Country:  -    
Other Details:
Languages:  ENG     Pagination:  0     Citation Subset:  -    
Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden - the Netherlands.
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