Document Detail


Uricosuric effect of losartan in patients with renal transplants.
MedLine Citation:
PMID:  11544429     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The aim of the study was to evaluate the uricosuric effect of the angiotensin II receptor antagonist, losartan, in hypertensive patients with renal transplants who are treated with cyclosporin A (CsA). METHODS: Twenty-six patients with stable renal function and hypertension, 16 men and 10 women, median age 47 years (range, 25-63 years), were studied in an open randomized crossover trial, comparing a 2-week control period with a 2-week period of once-daily administration of 50 mg of losartan. The main outcome measurements were fractional excretion of uric acid (FE(uric acid)) based on 24-hr urine collections and plasma uric acid. RESULTS: The median FE(uric acid) was 5.7% (range, 2.4-10.4%) in the control period with a median change of +0.84% (range, -1.15% to +2.77%) in the losartan period (P<0.0002). Plasma uric acid was 0.47 mM (0.29-0.69 mM) in the control period with a change of -0.03 mM (-0.10 to 0.06 mM) in the losartan period (P<0.002). Diastolic blood pressure was 87 mmHg (70-97 mmHg) in the control period with a change of -3 mmHg (-13 to +6 mmHg) in the losartan period (P<0.005). There was no difference in systolic blood pressure between the two study periods. Plasma creatinine was 165 microM (102-356 microM) in the control period with a change of +9 microM (-36 to +60 microM) in the losartan period (P<0.01). Plasma potassium was 4.2 mM (3.0-4.7 mM) in the control period with a change of + 0.2 mM (-0.2 to +0.9 mM) in the losartan period (P<0.0005). CONCLUSIONS: Once-daily administration of 50 mg of losartan in hypertensive CsA-treated patients with renal transplants caused a 17% increase in FE(uric acid) and an 8% fall in plasma uric acid.
Authors:
A L Kamper; A H Nielsen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Transplantation     Volume:  72     ISSN:  0041-1337     ISO Abbreviation:  Transplantation     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-09-06     Completed Date:  2001-09-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  671-4     Citation Subset:  IM    
Affiliation:
Department of Nephrology, Herlev Hospital, University of Copenhagen, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cross-Over Studies
Cyclosporine / therapeutic use
Drug Administration Schedule
Female
Humans
Hypertension / physiopathology
Immunosuppressive Agents / therapeutic use
Kidney Transplantation*
Losartan / administration & dosage,  therapeutic use*
Male
Middle Aged
Receptors, Angiotensin / antagonists & inhibitors*
Reference Values
Uric Acid / blood,  urine*
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents; 0/Receptors, Angiotensin; 114798-26-4/Losartan; 59865-13-3/Cyclosporine; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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