| Uric acid--a uremic toxin? | |
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MedLine Citation:
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PMID: 16361844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Uric acid might often be regarded as a simple marker of renal disease. Although it is well known that hyperuricemia causes gout which is associated with renal insufficiency and cardiovascular disease, one might think that it could attribute to the intrarenal urate crystal, but not to uric acid per se. In order to clarify the role of uric acid in the kidney, we hypothesized that uric acid causes renal disease. To generate mild hyperuricemia without intrarenal crystal in rats, we used low doses of an uricase inhibitor (2% oxonic acid). Hyperuricemia induced systemic hypertension, glomerular hypertrophy/hypertension, afferent arteriolar sclerosis, and macrophage infiltration in normal rat kidney. In progressive renal disease, such as cyclosporine nephropathy and remnant kidney in rat, uric acid accelerated the progression of renal disease. Thus, we concluded that uric acid is not a simple marker, but a cause of renal disease. |
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Authors:
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Takahiko Nakagawa; Marilda Mazzali; Duk-Hee Kang; L Gabriela Sánchez-Lozada; Jaime Herrera-Acosta; Richard J Johnson |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Blood purification Volume: 24 ISSN: 0253-5068 ISO Abbreviation: Blood Purif. Publication Date: 2006 |
Date Detail:
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Created Date: 2005-12-19 Completed Date: 2006-03-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8402040 Medline TA: Blood Purif Country: Switzerland |
Other Details:
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Languages: eng Pagination: 67-70 Citation Subset: IM |
Copyright Information:
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Copyright 2006 S. Karger AG, Basel. |
Affiliation:
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Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610-0224, USA. nakagt@medicine.ufl.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteriosclerosis / etiology, metabolism, pathology Biological Markers / metabolism Enzyme Inhibitors / administration & dosage, toxicity Humans Hypertension / etiology, metabolism, pathology Hypertrophy / etiology, metabolism, pathology Hyperuricemia / chemically induced, complications, metabolism*, pathology Kidney / metabolism, pathology Kidney Diseases / etiology, metabolism, pathology Oxonic Acid / administration & dosage, toxicity Rats Urate Oxidase / antagonists & inhibitors, metabolism Uric Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Enzyme Inhibitors; 69-93-2/Uric Acid; 937-13-3/Oxonic Acid; EC 1.7.3.3/Urate Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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