Document Detail

Uric acid--a uremic toxin?
MedLine Citation:
PMID:  16361844     Owner:  NLM     Status:  MEDLINE    
Uric acid might often be regarded as a simple marker of renal disease. Although it is well known that hyperuricemia causes gout which is associated with renal insufficiency and cardiovascular disease, one might think that it could attribute to the intrarenal urate crystal, but not to uric acid per se. In order to clarify the role of uric acid in the kidney, we hypothesized that uric acid causes renal disease. To generate mild hyperuricemia without intrarenal crystal in rats, we used low doses of an uricase inhibitor (2% oxonic acid). Hyperuricemia induced systemic hypertension, glomerular hypertrophy/hypertension, afferent arteriolar sclerosis, and macrophage infiltration in normal rat kidney. In progressive renal disease, such as cyclosporine nephropathy and remnant kidney in rat, uric acid accelerated the progression of renal disease. Thus, we concluded that uric acid is not a simple marker, but a cause of renal disease.
Takahiko Nakagawa; Marilda Mazzali; Duk-Hee Kang; L Gabriela Sánchez-Lozada; Jaime Herrera-Acosta; Richard J Johnson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Blood purification     Volume:  24     ISSN:  0253-5068     ISO Abbreviation:  Blood Purif.     Publication Date:  2006  
Date Detail:
Created Date:  2005-12-19     Completed Date:  2006-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8402040     Medline TA:  Blood Purif     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  67-70     Citation Subset:  IM    
Copyright Information:
Copyright 2006 S. Karger AG, Basel.
Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610-0224, USA.
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MeSH Terms
Arteriosclerosis / etiology,  metabolism,  pathology
Biological Markers / metabolism
Enzyme Inhibitors / administration & dosage,  toxicity
Hypertension / etiology,  metabolism,  pathology
Hypertrophy / etiology,  metabolism,  pathology
Hyperuricemia / chemically induced,  complications,  metabolism*,  pathology
Kidney / metabolism,  pathology
Kidney Diseases / etiology,  metabolism,  pathology
Oxonic Acid / administration & dosage,  toxicity
Urate Oxidase / antagonists & inhibitors,  metabolism
Uric Acid / metabolism*
Reg. No./Substance:
0/Biological Markers; 0/Enzyme Inhibitors; 69-93-2/Uric Acid; 937-13-3/Oxonic Acid; EC Oxidase

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