Document Detail

Uric acid transport and disease.
MedLine Citation:
PMID:  20516647     Owner:  NLM     Status:  MEDLINE    
Uric acid is the metabolic end product of purine metabolism in humans. It has antioxidant properties that may be protective but can also be pro-oxidant, depending on its chemical microenvironment. Hyperuricemia predisposes to disease through the formation of urate crystals that cause gout, but hyperuricemia, independent of crystal formation, has also been linked with hypertension, atherosclerosis, insulin resistance, and diabetes. We discuss here the biology of urate metabolism and its role in disease. We also cover the genetics of urate transport, including URAT1, and recent studies identifying SLC2A9, which encodes the glucose transporter family isoform Glut9, as a major determinant of plasma uric acid levels and of gout development.
Alexander So; Bernard Thorens
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-06-01
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  120     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-02     Completed Date:  2010-06-21     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1791-9     Citation Subset:  AIM; IM    
Service de Rhumatologie, Department of Musculoskeletal Medicine, University of Lausanne, Lausanne, Switzerland.
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MeSH Terms
Biological Transport / genetics
Glucose Transport Proteins, Facilitative / genetics,  metabolism*
Gout / etiology*,  genetics,  metabolism
Hypertension / complications*,  genetics,  metabolism
Hyperuricemia / etiology,  genetics,  metabolism*
Uric Acid / blood,  metabolism*
Reg. No./Substance:
0/Glucose Transport Proteins, Facilitative; 69-93-2/Uric Acid

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