Document Detail

Uric acid stones following hepatic transplantation.
MedLine Citation:
PMID:  15565437     Owner:  NLM     Status:  MEDLINE    
We report the case of a 52 year old man with a history of insulin-requiring diabetes and hepatitis B with cirrhosis who received an orthotopic liver transplant. One year later he developed renal colic and was found to have a 3 mm stone at the left ureterovesical junction. Numerous other stones formed and infrared spectroscopy analysis demonstrated all to be composed of 100% uric acid. Urine collections demonstrated a low urine pH of 5.1 without hyperuricosuria. His stones were effectively prevented with potassium citrate therapy. Few incidence data are available for uric acid stone occurrence in solid organ recipients. Calcineurin inhibitors are thought to often cause hyperuricemia on the basis of decreased urate excretion. However, this effect would not be expected to cause hyperuricosuria nor uric acid stones. This class of drugs may also be associated with low urine pH, perhaps on the basis of hypoaldosteronism, but the contribution of such a syndrome to uric acid stone formation is not established.
Mei-Tsuey Hwang; David S Goldfarb
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2004-11-25
Journal Detail:
Title:  Urological research     Volume:  32     ISSN:  0300-5623     ISO Abbreviation:  Urol. Res.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-23     Completed Date:  2005-08-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0364311     Medline TA:  Urol Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  423-6     Citation Subset:  IM    
Renal Section, Vanderbilt University School of Medicine, Nashville, TN, USA.
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MeSH Terms
Calcineurin / antagonists & inhibitors
Cyclosporine / adverse effects
Hydrogen-Ion Concentration
Immunosuppressive Agents / adverse effects
Kidney Calculi / chemistry,  diagnosis,  etiology*
Lithiasis / diagnosis,  etiology*
Liver Transplantation*
Middle Aged
Tacrolimus / adverse effects
Uric Acid / analysis*,  urine
Reg. No./Substance:
0/Immunosuppressive Agents; 109581-93-3/Tacrolimus; 59865-13-3/Cyclosporine; 69-93-2/Uric Acid; EC

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