Document Detail

Uric acid protects erythrocytes from ozone-induced changes.
MedLine Citation:
PMID:  3608939     Owner:  NLM     Status:  MEDLINE    
Uric acid effectively reduced hemolysis and methemoglobin formation in bovine and swine erythrocytes bubbled with ozone in vitro. In bovine erythrocytes, formation of thiobarbituric acid-reactive material was inhibited by uric acid, but there was little immediate protection for the swine cells. Antioxidant protection was due to preferential degradation of the uric acid by ozone. These results provide evidence to support the hypothesis that in plasma, uric acid can provide antioxidant protection for erythrocytes.
J Meadows; R C Smith
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Environmental research     Volume:  43     ISSN:  0013-9351     ISO Abbreviation:  Environ. Res.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-09-18     Completed Date:  1987-09-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  410-6     Citation Subset:  IM    
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MeSH Terms
Erythrocytes / drug effects*,  physiology
Hemolysis / drug effects*
Lipid Peroxides / blood
Methemoglobin / metabolism
Ozone / toxicity*
Uric Acid / pharmacology*
Reg. No./Substance:
0/Lipid Peroxides; 10028-15-6/Ozone; 69-93-2/Uric Acid; 9008-37-1/Methemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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