Document Detail


Uric acid: the oxidant-antioxidant paradox.
MedLine Citation:
PMID:  18600514     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Uric acid, despite being a major antioxidant in the human plasma, both correlates and predicts development of obesity, hypertension, and cardiovascular disease, conditions associated with oxidative stress. While one explanation for this paradox could be that a rise in uric acid represents an attempted protective response by the host, we review the evidence that uric acid may function either as an antioxidant (primarily in plasma) or pro-oxidant (primarily within the cell). We suggest that it is the pro-oxidative effects of uric acid that occur in cardiovascular disease and may have a contributory role in the pathogenesis of these conditions.
Authors:
Yuri Y Sautin; Richard J Johnson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nucleosides, nucleotides & nucleic acids     Volume:  27     ISSN:  1532-2335     ISO Abbreviation:  Nucleosides Nucleotides Nucleic Acids     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-07-07     Completed Date:  2008-10-30     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  100892832     Medline TA:  Nucleosides Nucleotides Nucleic Acids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  608-19     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / metabolism*
Humans
Inflammation / metabolism
Oxidants / metabolism*
Uric Acid / metabolism*
Grant Support
ID/Acronym/Agency:
HL-68607/HL/NHLBI NIH HHS; R01 HL068607/HL/NHLBI NIH HHS; R01 HL068607-07A2/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Oxidants; 268B43MJ25/Uric Acid
Comments/Corrections

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