Document Detail


Uric acid, monosodium urate and ammonium urate urinary relative saturations in normo-uricuric calcium oxalate stone formers.
MedLine Citation:
PMID:  7389778     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Monosodium urate (NaU), ammonium urate (NH4U) and uric acid (UA) urinary relative saturations were studied in 15 normo-uricuric calcium oxalate (CaOx) recurrent stone formers whose CaOx relative saturation was identical to age- and sex-matched controls. NaU and NH4U relative saturations were constantly below 1 and not higher in stone formers than in controls, suggesting that heterogeneous nucleation is an unlikely mechanism of CaOx stone formation in vivo. Such values of NaU relative saturation would also tend to rule out any change in the CaOx formation product or urinary inhibitory activity. However, at a given urinary flow rate, NaU relative saturation was suggestively higher in stone formers than in controls. Some disturbance in the equilibrium between NaU and urinary inhibitors might then exist even in normo-uricuric CaOx stone formers.
Authors:
M Labeeuw; C Gerbaulet; N Pozet; P Zech; P Divry; J Traeger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European urology     Volume:  6     ISSN:  0302-2838     ISO Abbreviation:  Eur. Urol.     Publication Date:  1980  
Date Detail:
Created Date:  1980-09-26     Completed Date:  1980-09-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7512719     Medline TA:  Eur Urol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  241-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Calcium Oxalate / urine*
Male
Uric Acid / urine*
Urinary Calculi / pathology*
Chemical
Reg. No./Substance:
25454-23-3/Calcium Oxalate; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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