Document Detail


Uric acid metabolism in homozygous and heterozygous muscular dystrophic mice.
MedLine Citation:
PMID:  645859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The homozygous muscular dystrophic mice (dydy) were found to have significantly higher plasma uric acid than their heterozygous littermate controls (Dydy), and the Swiss albino mice. Because the rate of uric acid excretion did not compensate for the elevated plasma levels, U/P (urine/plasma) urate was lower in dydy mice. With RNA supplement, plasma and urinary urate were increased in both dydy and Dydy mice; again U/P urate was lower in dydy mice. It appears that the dydy mice to a certain extent are comparable to some gouty subjects, whose hyperuricemia is not accompanied by a corresponding increase in urinary uric acid. There was no difference in converting uric acid to allantoin either on basal diet alone or with RNA supplement. Oxonic acid effectively, though transiently, blocked the uricase activity in both dydy and Dydy mice resulting in hyperuricemia and hyperuricosuria with decreased allantoin. Uric acid content was increased markedly in the kidney without histological evidence of urate deposition, apparently related to the unsustained effect of oxonic acid, which was rapidly excreted.
Authors:
M Y Dju; T F Yü
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  234     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1978 Apr 
Date Detail:
Created Date:  1978-06-12     Completed Date:  1978-06-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E421-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Allantoin / metabolism
Animals
Diet
Heterozygote
Homozygote
Kidney / metabolism
Liver / metabolism
Male
Mice
Mice, Inbred ICR
Mice, Inbred Strains
Muscular Dystrophy, Animal / genetics,  metabolism*
RNA / administration & dosage
Uric Acid / metabolism*
Chemical
Reg. No./Substance:
63231-63-0/RNA; 69-93-2/Uric Acid; 97-59-6/Allantoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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