Document Detail

Uric acid metabolism in children.
MedLine Citation:
PMID:  2330229     Owner:  NLM     Status:  MEDLINE    
The renal excretion of uric acid in children differs quantitatively, and perhaps qualitatively, from that in adult humans. The younger the child, the greater the renal clearance of uric acid and the greater the excretion of uric acid expressed as mg per kg body weight. During infancy, the reduced ability to maximally concentrate the urine may protect against precipitation of uric acid crystals within the kidney. Conversely, the extremely high urinary uric concentrations places the very small infant at jeopardy during sudden increases in the filtered load of uric acid. Understanding the pharmacologic and physiologic modulators of renal uric acid clearance will allow the pediatrician to minimize the risk of uric acid nephropathy, and to understand the implications of uric acid in the serum or urine in children with fluid and electrolyte disorders. Certainly evaluation of serum and urinary uric acid concentrations is essential in any child with acute renal failure.
L A Baldree; F B Stapleton
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric clinics of North America     Volume:  37     ISSN:  0031-3955     ISO Abbreviation:  Pediatr. Clin. North Am.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-05-25     Completed Date:  1990-05-25     Revised Date:  2011-12-06    
Medline Journal Info:
Nlm Unique ID:  0401126     Medline TA:  Pediatr Clin North Am     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  391-418     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Tennessee, Memphis.
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MeSH Terms
Biological Transport
Infant, Newborn
Kidney / metabolism
Kidney Diseases / metabolism
Metabolic Diseases / metabolism
Reference Values
Uric Acid / blood,  metabolism*,  urine
Grant Support
2MO1 BR00211-24/BR/FDA HHS
Reg. No./Substance:
69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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