Document Detail

Uric acid levels in patients with multiple sclerosis: analysis in mono- and dizygotic twins.
MedLine Citation:
PMID:  11475439     Owner:  NLM     Status:  MEDLINE    
Presence of nitrotyrosine in cells surrounding plaques indicates that peroxynitrite may be the cause of brain lesions in multiple sclerosis. Low levels of uric acid, a natural scavenger of peroxynitrite, were demonstrated in blood of patients with multiple sclerosis in comparison with control individuals. These observations were now extended to 132 sets of twins with one sibling affected by multiple sclerosis. In blood of both mono- and dizygotic twins the uric acid levels were lower in the twin with the disease than in the healthy twin.
S Spitsin; D C Hooper; T Mikheeva; H Koprowski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Twin Study    
Journal Detail:
Title:  Multiple sclerosis (Houndmills, Basingstoke, England)     Volume:  7     ISSN:  1352-4585     ISO Abbreviation:  Mult. Scler.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-07-27     Completed Date:  2001-12-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9509185     Medline TA:  Mult Scler     Country:  England    
Other Details:
Languages:  eng     Pagination:  165-6     Citation Subset:  IM    
Department of Immunology & Microbiology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
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MeSH Terms
Multiple Sclerosis / blood*
Twins, Dizygotic
Twins, Monozygotic
Uric Acid / blood*
Reg. No./Substance:
69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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