Document Detail

Uric acid levels are correlated with baseline renal function and high levels are a potent risk factor for postoperative chronic kidney disease in patients with renal cell carcinoma.
MedLine Citation:
PMID:  23159461     Owner:  NLM     Status:  Publisher    
PURPOSE:: We investigated the relationship between preoperative uric acid levels and GFR preoperatively and postoperatively in patients with RCC. MATERIALS AND METHODS:: We included 1,534 patients who underwent radical or partial nephrectomy for RCC between 1994 and 2008. Uric acid was measured preoperatively and estimated GFR was calculated using the modification of diet in renal disease equation preoperatively and postoperatively within 7 days and at 3 months, 1 year, and 3 years. We looked for correlations of uric acid with GFR, patient demographics, and comorbidities. We also evaluated the predictive value of uric acid for preoperative GFR and new-onset chronic kidney disease (GFR<60mL/min/1.73m(2)) after nephrectomy using multivariate regression analysis. RESULTS:: The mean uric acid (SD, range) concentration was 5.2 (1.5, 1.3-11.3)mg/dL. The mean preoperative uric acid level was correlated with preoperative GFR (r=-0.313, p<0.001) and associated with prevalent chronic kidney disease. Decreased preoperative GFR correlated significantly with earlier year of surgery (p<0.001), old age (p<0.001), male gender (p<0.001), hypertension (p<0.001), high uric acid level (p<0.001), and larger tumor size (p<0.001) in multivariate regression analysis. Hypertension (p<0.001), male gender (p<0.001), and a high body mass index (p<0.001) were correlated with high levels of uric acid. Older age (p<0.001), diabetes mellitus (p=0.002), a low preoperative GFR (p<0.001), and a high preoperative uric acid level (p=0.002) were significant predictors of new-onset chronic kidney disease at 3 years after nephrectomy. CONCLUSIONS:: The elevated preoperative uric acid level was an independent predictor of low preoperative GFR and new-onset chronic kidney disease in RCC patients who underwent nephrectomy.
Hwang Gyun Jeon; Seol Ho Choo; Byung Chang Jeong; Seong Il Seo; Seong Soo Jeon; Han Yong Choi; Hyun Moo Lee
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-13
Journal Detail:
Title:  The Journal of urology     Volume:  -     ISSN:  1527-3792     ISO Abbreviation:  J. Urol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.
Department of Urology, Samsung Medical Center, Sungkyunkwan University, Seoul, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Bluetongue virus serotype 8 virus-like particles protect sheep against virulent virus infection as a...
Next Document:  Association between Warm Ischemia Time and Renal Parenchymal Atrophy after Partial Nephrectomy.