Document Detail


Uric acid in multiple sclerosis.
MedLine Citation:
PMID:  16687059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peroxynitrite, a reactive oxidant formed by the reaction of nitric oxide with superoxide at sites of inflammation in multiple sclerosis (MS), is capable of damaging tissues and cells. Uric acid, a natural scavenger of peroxynitrite, reduces inflammatory demyelination in experimental allergic encephalomyelitis. Some studies reported lower serum levels of uric acid in MS patients compared with controls, whereas other studies found no difference. A critical appraisal of these studies favors the view that reduced uric acid in MS is secondary to its peroxynitrite scavenging activity during inflammatory disease activity, rather than a primary deficiency. Serum uric acid levels could be used as a biomarker for monitoring disease activity in MS. Therapeutic strategies aimed at raising serum uric acid levels may have a glial/neuroprotective effect on MS patients.
Authors:
Marcus Koch; Jacques De Keyser
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Neurological research     Volume:  28     ISSN:  0161-6412     ISO Abbreviation:  Neurol. Res.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-05-11     Completed Date:  2006-07-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  316-9     Citation Subset:  IM    
Affiliation:
Department of Neurology, University Medical Centre Groningen, University of Groningen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / therapeutic use
Biological Markers
Humans
Multiple Sclerosis / drug therapy,  etiology,  metabolism*
Uric Acid / metabolism*,  therapeutic use
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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