| Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity. | |
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MedLine Citation:
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PMID: 12215479 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Humans have elevated serum uric acid as a result of a mutation in the urate oxidase (uricase) gene that occurred during the Miocene. We hypothesize that the mutation provided a survival advantage because of the ability of hyperuricemia to maintain blood pressure under low-salt dietary conditions, such as prevailed during that period. Mild hyperuricemia in rats acutely increases blood pressure by a renin-dependent mechanism that is most manifest under low-salt dietary conditions. Chronic hyperuricemia also causes salt sensitivity, in part by inducing preglomerular vascular disease. The vascular disease is mediated in part by uric acid-induced smooth muscle cell proliferation with activation of mitogen-activated protein kinases and stimulation of cyclooxygenase-2 and platelet-derived growth factor. Although it provided a survival advantage to early hominoids, hyperuricemia may have a major role in the current cardiovascular disease epidemic. |
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Authors:
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Susumu Watanabe; Duk-Hee Kang; Lili Feng; Takahiko Nakagawa; John Kanellis; Hui Lan; Marilda Mazzali; Richard J Johnson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Hypertension Volume: 40 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-09-06 Completed Date: 2002-09-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 355-60 Citation Subset: IM |
Affiliation:
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Division of Nephrology, Baylor College of Medicine, Houston, Tex 77030, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure* Cardiovascular Diseases / etiology Cell Division Cells, Cultured Developed Countries Evolution, Molecular* Humans Hypertension / etiology Kidney Diseases / etiology Kinetics Models, Cardiovascular* Muscle, Smooth, Vascular / cytology, drug effects Mutation Rats Rats, Sprague-Dawley Sodium Chloride, Dietary* Urate Oxidase / genetics Uric Acid / blood*, pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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DK-52121/DK/NIDDK NIH HHS; HL-68607/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Sodium Chloride, Dietary; 69-93-2/Uric Acid; EC 1.7.3.3/Urate Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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