Document Detail

Uric acid and the development of hypertension.
MedLine Citation:
PMID:  20885365     Owner:  NLM     Status:  MEDLINE    
Uric acid is a major product of purine metabolism in humans. Epidemiologic and experimental evidence suggests that serum uric acid is an independent risk factor for developing hypertension. Several plausible mechanisms have been proposed to explain how hyperuricemia is related to hypertension. In this review we summarize the current understanding concerning uric acid and the development of hypertension based on a MEDLINE search of all peer-review publications (original articles and reviews) on this topic between 1965 and 2009, focusing on papers published in the last 2 decades. The results from animal studies and clinical observations support renal microvascular and tubulointerstitial injury being the key to uric acid-induced hypertension. Associations with other systemic derangements, including endothelial dysfunction, low-level systemic inflammation, sympathetic overactivity and insulin resistance, render uric acid to a complex but potentially direct causal role in the pathogenesis of hypertension. The identification of conceivable biological mechanisms by which uric acid could cause high blood pressure has led to new insights about therapeutic modalities that may control high blood pressure and cardiovascular outcomes. Although there is still no consensus on the treatment of individuals with asymptomatic hyperuricemia, it is time to reappraise potential approaches for these subjects with regard to prevention of hypertension and related renal and cardiovascular complications.
Chii-Min Hwu; Kuan-Hung Lin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Medical science monitor : international medical journal of experimental and clinical research     Volume:  16     ISSN:  1643-3750     ISO Abbreviation:  Med. Sci. Monit.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2011-04-18     Revised Date:  2011-06-14    
Medline Journal Info:
Nlm Unique ID:  9609063     Medline TA:  Med Sci Monit     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  RA224-30     Citation Subset:  IM    
Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
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MeSH Terms
Cross-Sectional Studies
Hypertension / blood,  etiology*,  metabolism
Hyperuricemia / blood,  complications,  physiopathology
Insulin Resistance
Kidney / metabolism,  physiopathology
Retrospective Studies
Risk Factors
Uric Acid / blood*,  metabolism*
Vascular Diseases / complications
Reg. No./Substance:
69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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