| Uric acid and IGF1 as possible determinants of FGF23 metabolism in children with normal renal function. | |
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MedLine Citation:
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PMID: 22311343 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone and a suppressor of renal 1α hydroxylase. Although circulating values of FGF23 are increased in early chronic kidney disease (CKD), the interplay between FGF23 levels, growth and nutritional biomarkers has not been evaluated in children with normal renal function. METHODS: We performed a secondary analysis of the cross-sectional observational INU23 study in 98 children (51 boys, mean age 10.5 ± 3.9 years) with preserved renal function (glomerular filtration rate (GFR) 114 ± 14 ml/min/1.73 m(2)). RESULTS: In bivariate analyses, C-terminal FGF23 levels were positively related to phosphorus and uric acid levels. Intact FGF23 levels were positively associated with uric acid and insulin growth factor 1 (IGF1) levels, with similar results for age, body mass index (BMI), and 25OH vitamin D (25(OH)D). By multivariable analyses, 25(OH)D, uric acid, and phosphorus were independent predictors of C-terminal FGF23, while 25(OH)D, uric acid, and IGF1 were independent predictors of intact FGF23. CONCLUSIONS: In children with preserved kidney function, the association between FGF23, uric acid, and IGF1 suggests that FGF23 could be an early nutritional indicator of high protein and phosphate intake. The association between FGF23 and IGF1 also suggests a relationship between FGF23 and growth, and warrants further investigation. |
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Authors:
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Justine Bacchetta; Pierre Cochat; Isidro B Salusky; Katherine Wesseling-Perry |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-5 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: - ISSN: 1432-198X ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Centre de Référence des Maladies Rénales Rares, Service de Néphrologie et Rhumatologie Pédiatriques, Hôpital Femme Mère Enfant, 59 Bd Pinel, 69677, Bron, France, j.bacchetta@laposte.net. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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