Document Detail

Uric Acid stones and hyperuricosuria.
MedLine Citation:
PMID:  23089277     Owner:  NLM     Status:  In-Data-Review    
Recent work has highlighted the strong relationships among obesity, diabetes, and the metabolic syndrome as causes of low urinary pH. Low urinary pH in turn is the major urinary risk factor for uric acid stones. Unlike calcium stones, uric acid stones can be dissolved and easily prevented with adequate urinary alkalinization. Recognizing the relevant risk factors should lead to increased identification of these radiolucent stones. The cornerstone of therapy is raising urinary pH; xanthine dehydrogenase inhibitors should be used only when urinary alkalinization cannot be achieved.
Tapan H Mehta; David S Goldfarb
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in chronic kidney disease     Volume:  19     ISSN:  1548-5609     ISO Abbreviation:  Adv Chronic Kidney Dis     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101209214     Medline TA:  Adv Chronic Kidney Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  413-8     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
Department of Medicine, New York University Langone Medical Center, New York, NY; and Nephrology Section, New York Harbor VA Healthcare System, and Endourology Section, Lenox Hill Hospital and Division of Nephrology, New York University Langone Medical Center, New York, NY.
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