Document Detail


Uric Acid is not an independent predictor of cardiovascular death in patients with angiographically proven coronary artery disease.
MedLine Citation:
PMID:  20035639     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The aim of this study is to investigate the impact of uric acid on clinical outcomes in patients with angiographically proven coronary artery disease.
METHOD: Six hundred and forty seven consecutive patients with angiographically proven significant coronary artery disease were enrolled in this retrospective study. Patients were assigned to serum uric acid level >or= 6.4 mg/dL and < 6.4 mg/dL groups based on baseline fasting uric acid levels and determined by a receiver operating characteristic curve. The mean follow-up duration was 4.6 +/- 1.1 years after coronary angiography. The primary endpoints were all cause mortality and death from cardiovascular disease.
RESULTS: The five-year survival rates for patients free from all-cause mortality with levels of uric acid >or= 6.4 mg/dL and < 6.4 mg/dL were 82% and 92% respectively (p < 0.0001). Five-year survival rates for patients free from cardiovascular mortality with levels of uric acid uric acid >or= 6.4 mg/dL and < 6.4 mg/dL were 91% and 97% respectively (p = 0.003). Multivariate Cox regression analysis showed that serum uric acid was an independent predictor of all-cause death (p = 0.01) but was not an independent predictor of cardiovascular mortality (p = 0.063) after adjusting for multi-vessel coronary artery disease, chronic renal insufficiency and a left ventricular ejection fraction < 40%.
CONCLUSIONS: After multivariate adjustment, the fasting serum uric acid level was an independent predictor of all-cause mortality, but probably not an independent predictor of cardiovascular mortality in patients with angiographically proven coronary artery disease.
Authors:
Tzu-Hsien Tsai; Yung-Lung Chen; Shyh-Ming Chen; Cheng-Hsu Yang; Chih-Yuan Fang; Yuan-Kai Hsieh; Chiung-Jen Wu; Hon-Kan Yip; Chi-Ling Hang; Morgan Fu; Mien-Cheng Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chang Gung medical journal     Volume:  32     ISSN:  2309-835X     ISO Abbreviation:  Chang Gung Med J     Publication Date:    2009 Nov-Dec
Date Detail:
Created Date:  2009-12-28     Completed Date:  2010-03-10     Revised Date:  2013-10-22    
Medline Journal Info:
Nlm Unique ID:  101088034     Medline TA:  Chang Gung Med J     Country:  China (Republic : 1949- )    
Other Details:
Languages:  eng     Pagination:  605-13     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital - Kaohsiung Medical Center, Chang Gung University College of Medicine, Niaosong Township, Kaohsiung County 833, Taiwan (R.O.C.).
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MeSH Terms
Descriptor/Qualifier:
Aged
Cardiovascular Diseases / mortality*
Coronary Angiography
Coronary Artery Disease / blood*
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Retrospective Studies
Uric Acid / blood*
Chemical
Reg. No./Substance:
69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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