| Uric Acid and hypertension. | |
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MedLine Citation:
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PMID: 22000651 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A link between serum uric acid and the development of hypertension was first hypothesized in the 1870s. Although numerous epidemiologic studies in the 1980s and 1990s suggested an association, relatively little attention was paid to it until recently. Animal models have suggested a two-step pathogenesis by which uric acid initially activates the renin angiotensin system and suppresses nitric oxide, leading to uric acid-dependent increase in systemic vascular resistance, followed by a uric acid-mediated vasculopathy, involving renal afferent arterioles, resulting in a late sodium-sensitive hypertension. Initial clinical trials in young patients have supported these mechanisms in young patients but do not yet support pharmacologic reduction of serum uric acid as first-line therapy for hypertension. |
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Authors:
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Daniel I Feig |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Seminars in nephrology Volume: 31 ISSN: 1558-4488 ISO Abbreviation: Semin. Nephrol. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-10-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8110298 Medline TA: Semin Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 441-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
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Division of Nephrology, Department of Pediatrics, University of Alabama, Birmingham School of Medicine, Birmingham, AL. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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