| Uric acid and hypertension: cause or effect? | |
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MedLine Citation:
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PMID: 20425019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Uric acid was first associated with primary hypertension in 1874, yet its role in this condition remains unclear. Historically, uric acid was thought to be a secondary response to hypertension or its associated conditions. However, more recent experimental and clinical studies suggest that uric acid could have a contributory role in the pathogenesis of elevated blood pressure. More studies are needed to help dissect the potential mechanisms by which uric acid could initiate this response. It remains possible that uric acid is a marker for xanthine oxidase-associated oxidants and that the latter could be driving the hypertensive response. However, the weight of the evidence suggests that uric acid is a true modifying and possibly causal factor for human primary hypertension. Hence, early management of hyperuricemia might delay the development of essential hypertension. |
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Authors:
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Marilda Mazzali; Mehmet Kanbay; Mark S Segal; Mohamed Shafiu; Diana Jalal; Daniel I Feig; Richard J Johnson |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current rheumatology reports Volume: 12 ISSN: 1534-6307 ISO Abbreviation: Curr Rheumatol Rep Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-28 Completed Date: 2010-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888970 Medline TA: Curr Rheumatol Rep Country: United States |
Other Details:
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Languages: eng Pagination: 108-17 Citation Subset: IM |
Affiliation:
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Division of Renal Diseases and Hypertension, University of Colorado-Denver, Aurora, CO 80045, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Allopurinol
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therapeutic use Blood Pressure / physiology Gout Suppressants / therapeutic use Humans Hypertension / blood, complications*, physiopathology Hyperuricemia / complications*, drug therapy, physiopathology Uric Acid / blood |
| Chemical | |
Reg. No./Substance:
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0/Gout Suppressants; 315-30-0/Allopurinol; 69-93-2/Uric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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