Document Detail


Uric acid and hypertension: cause or effect?
MedLine Citation:
PMID:  20425019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Uric acid was first associated with primary hypertension in 1874, yet its role in this condition remains unclear. Historically, uric acid was thought to be a secondary response to hypertension or its associated conditions. However, more recent experimental and clinical studies suggest that uric acid could have a contributory role in the pathogenesis of elevated blood pressure. More studies are needed to help dissect the potential mechanisms by which uric acid could initiate this response. It remains possible that uric acid is a marker for xanthine oxidase-associated oxidants and that the latter could be driving the hypertensive response. However, the weight of the evidence suggests that uric acid is a true modifying and possibly causal factor for human primary hypertension. Hence, early management of hyperuricemia might delay the development of essential hypertension.
Authors:
Marilda Mazzali; Mehmet Kanbay; Mark S Segal; Mohamed Shafiu; Diana Jalal; Daniel I Feig; Richard J Johnson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current rheumatology reports     Volume:  12     ISSN:  1534-6307     ISO Abbreviation:  Curr Rheumatol Rep     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-28     Completed Date:  2010-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888970     Medline TA:  Curr Rheumatol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  108-17     Citation Subset:  IM    
Affiliation:
Division of Renal Diseases and Hypertension, University of Colorado-Denver, Aurora, CO 80045, USA.
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MeSH Terms
Descriptor/Qualifier:
Allopurinol / therapeutic use
Blood Pressure / physiology
Gout Suppressants / therapeutic use
Humans
Hypertension / blood,  complications*,  physiopathology
Hyperuricemia / complications*,  drug therapy,  physiopathology
Uric Acid / blood
Chemical
Reg. No./Substance:
0/Gout Suppressants; 315-30-0/Allopurinol; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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