Document Detail

Uric acid elevation in atrial fibrillation.
MedLine Citation:
PMID:  20515852     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Uric acid is a cardiovascular risk marker associated with oxidative stress and inflammation. Recently, atrial fibrillation (AF) has been associated with inflammation and oxidative stress. We therefore investigated the association between AF and uric acid levels.
METHODS: Consecutive patients with AF and healthy control subjects were screened. Demographic, clinical, and echocardiographic characteristics were carefully recorded. In each participant, uric acid levels and conventional inflammatory markers were determined. The final study population consisted of 45 patients with paroxysmal AF, 41 patients with permanent AF, and 48 control subjects.
RESULTS: A significant variance in uric acid levels was evident between patients with paroxysmal AF (5.7 +/- 1.1 mg/dl), permanent AF (6.7 +/- 1.4 mg/dl), and control subjects (5.1 +/- 1.3 mg/dl) (p<0.001). After univariate analysis considering 2 groups (control, AF patients), the following variables were significantly associated with the presence of AF: age, hypertension, -blocker use, low left ventricular ejection fraction (LVEF), increased left atrial diameter, uric acid levels, and C-reactive protein (CRP) levels. After multivariate logistic regression analysis, only CRP was an independent predictor for AF (odds ratio, OR: 2.172). In a subgroup analysis, CRP (OR: 1.434) and LVEF (OR: 0.361) were independent predictors of paroxysmal AF, while CRP (OR: 3.048), uric acid (OR: 2.172), and LVEF (OR: 0.34) were predictors of permanent AF.
CONCLUSIONS: There is an association between increased levels of uric acid and permanent AF. Also, uric acid elevation may be related to the burden of AF. Undoubtedly, larger studies should further examine this potential association.
Konstantinos P Letsas; Panagiotis Korantzopoulos; Gerasimos S Filippatos; Constantinos C Mihas; Virginia Markou; Gerasimos Gavrielatos; Michalis Efremidis; Antonios Sideris; Fotios Kardaras
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hellenic journal of cardiology : HJC = Hellēnikē kardiologikē epitheōrēsē     Volume:  51     ISSN:  2241-5955     ISO Abbreviation:  Hellenic J Cardiol     Publication Date:    2010 May-Jun
Date Detail:
Created Date:  2010-06-02     Completed Date:  2010-11-16     Revised Date:  2013-08-07    
Medline Journal Info:
Nlm Unique ID:  101257381     Medline TA:  Hellenic J Cardiol     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  209-13     Citation Subset:  IM    
Second Department of Cardiology, Evangelismos General Hospital of Athens, Greece.
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MeSH Terms
Atrial Fibrillation / blood*
Cross-Sectional Studies
Middle Aged
Uric Acid / blood*
Reg. No./Substance:
69-93-2/Uric Acid

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