Document Detail

Uremic Serum and Ubiquitylation of Tissue Factor.
MedLine Citation:
PMID:  23269490     Owner:  NLM     Status:  Publisher    
Stent thrombosis is a major clinical problem associated with a high rate of mortality.(1,2) The development of drug-eluting stents (DES) has significantly reduced restenosis compared with bare metal stents (BMS) due to the antiproliferative agents inhibiting vascular smooth muscle (VSMC) proliferation. However, the rate of stent thrombosis associated with DES continues to be a major concern with rates between 0.3 and 1.1% within 3 years.(1) Thrombosis is likely in part due to the fact that the antiproliferative drugs also inhibit re-endothelization of the vessel. Furthermore, patients with chronic renal failure have worse outcomes after stenting and have as much as an 8 fold increase in 1-year cardiac mortality following coronary intervention.(3).
Nigel Mackman
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-25
Journal Detail:
Title:  Circulation     Volume:  -     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
University of North Carolina at Chapel Hill, Chapel Hill, NC.
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