Document Detail

Ureaplasma species: role in diseases of prematurity.
MedLine Citation:
PMID:  20569814     Owner:  NLM     Status:  MEDLINE    
There is accumulating epidemiologic and experimental evidence that intrauterine or postnatal infection with Ureaplasma species is a significant risk factor for adverse pregnancy outcomes and complications of extreme preterm birth such as bronchopulmonary dysplasia and intraventricular hemorrhage. In a cohort of very low birth weight infants, Ureaplasma spp were detected by culture or polymerase chain reaction in respiratory secretions, blood, or cerebrospinal fluid of almost half of the subjects, suggesting that this organism is the most common pathogen affecting this population. This review summarizes the evidence supporting the hypothesis that Ureaplasma-mediated inflammation in different compartments (intrauterine, lung, blood, or brain) during a common developmental window of vulnerability contributes to preterm labor and lung and brain injury. Appropriate methods for detecting these fastidious organisms and potential strategies to prevent or ameliorate the effects of Ureaplasma infection are discussed.
Rose M Viscardi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Clinics in perinatology     Volume:  37     ISSN:  1557-9840     ISO Abbreviation:  Clin Perinatol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-23     Completed Date:  2010-10-14     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  393-409     Citation Subset:  IM    
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MeSH Terms
Infant, Newborn
Infant, Premature*
Infant, Premature, Diseases / epidemiology,  microbiology*,  prevention & control*
Infectious Disease Transmission, Vertical / prevention & control
Inflammation / microbiology
Pregnancy Complications, Infectious / epidemiology,  microbiology*,  prevention & control*
Ureaplasma / isolation & purification,  pathogenicity*
Ureaplasma Infections / epidemiology,  microbiology*,  prevention & control*
Grant Support
HL071113/HL/NHLBI NIH HHS; HL087166/HL/NHLBI NIH HHS; R01 HL071113/HL/NHLBI NIH HHS; R01 HL071113-01/HL/NHLBI NIH HHS; R01 HL071113-02/HL/NHLBI NIH HHS; R01 HL087166/HL/NHLBI NIH HHS; R01 HL087166-01/HL/NHLBI NIH HHS; R01 HL087166-02/HL/NHLBI NIH HHS; R01 HL087166-03/HL/NHLBI NIH HHS

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