| Ureaplasma parvum or Mycoplasma hominis as sole pathogens cause chorioamnionitis, preterm delivery, and fetal pneumonia in rhesus macaques. | |
| | |
MedLine Citation:
|
PMID: 19122105 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The authors assess causal, cellular and inflammatory links between intraamniotic infection with Ureaplasma parvum or Mycoplasma hominis and preterm labor in a nonhuman primate model. Long-term catheterized rhesus monkeys received intraamniotic inoculations of clinical isolates of Ureaplasma parvum serovar 1, M hominis, media control or physiological saline. Genital mycoplasmas were quantified in amniotic fluid (AF) and documented in fetal tissues by culture and PCR. In association with elevated AF colony counts for U parvum or M hominis, there was a sequential upregulation of AF leukocytes, proinflammatory cytokines, prostaglandin E2 and F2a, metalloproteinase-9 and uterine activity ( P< .05). Fetal membranes and lung were uniformly positive for both microorganisms; fetal blood and cerebrospinal fluid cultures and PCR were more often positive for M hominis than U parvum. Histopathologic findings of chorioamnionitis, a systemic fetal inflammatory response and pneumonitis worsen with duration of in utero infection. U parvum or M hominis, as sole pathogens, elicit a robust proinflammatory response which contributes to preterm labor and fetal lung injury. |
| | |
Authors:
|
Miles J Novy; Lynn Duffy; Michael K Axthelm; Drew W Sadowsky; Steven S Witkin; Michael G Gravett; Gail H Cassell; Kenneth B Waites |
Related Documents
:
|
6541805 - Lung retention of antimony and arsenic in hamsters after the intratracheal instillation... 12528165 - Treatment of severe fetal chylothorax associated with pronounced hydrops with intrapleu... 8719725 - Endoscopic tracheal obstruction with an expanding device in a fetal lamb model: prelimi... 761655 - Postnatal formation of alveoli: interstitial events and physiologic consequences. 1475295 - Antinociceptive properties of tiletamine-zolazepam improved by addition of xylazine or ... 17369295 - Vascular dysfunction during pregnancy in women with polycystic ovary syndrome. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-01-02 |
Journal Detail:
|
Title: Reproductive sciences (Thousand Oaks, Calif.) Volume: 16 ISSN: 1933-7205 ISO Abbreviation: Reprod Sci Publication Date: 2009 Jan |
Date Detail:
|
Created Date: 2009-01-15 Completed Date: 2009-03-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101291249 Medline TA: Reprod Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 56-70 Citation Subset: IM |
Affiliation:
|
Divisions of Reproductive Sciences Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA. novym@ohsu.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amniotic Fluid
/
microbiology Animals Chorioamnionitis / microbiology* Female Macaca mulatta Mycoplasma Infections / microbiology* Mycoplasma hominis / growth & development* Obstetric Labor, Premature / microbiology* Pneumonia / microbiology* Pregnancy Ureaplasma / growth & development* Ureaplasma Infections / microbiology* |
| Grant Support | |
ID/Acronym/Agency:
|
AI072577/AI/NIAID NIH HHS; AI42490/AI/NIAID NIH HHS; HD06159/HD/NICHD NIH HHS; HD18185/HD/NICHD NIH HHS; HD41676/HD/NICHD NIH HHS; RR00163/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: SQUAMOSA Promoter Binding Protein-Like7 Is a Central Regulator for Copper Homeostasis in Arabidopsis...
Next Document: Hepatitis B: a strategy for evaluation and management.