Document Detail

Urea reduction ratio that considers effects of ultrafiltration and intradialytic urea generation.
MedLine Citation:
PMID:  11228178     Owner:  NLM     Status:  MEDLINE    
We modified the urea reduction ratio (URR) equation to correct the effects of ultrafiltration and intradialytic urea generation on the delivered dose of hemodialysis: mURR = [1 - (R/1 + 2*UF/BW) + 0.01*t] x 100% where mURR is modified URR, R is postdialysis plasma urea nitrogen (PUN) to predialysis PUN ratio, UF is ultrafiltrate volume in liters, BW is postdialysis body weight in kilograms, and t is dialysis session length in hours. The equation was validated against 145 hemodialysis treatments on 33 stable maintenance dialysis patients. The mURR values obtained closely predicted single-pool Kt/V (spKt/V) values. In contrast to conventional URR, the range of spKt/V values at each mURR value is narrow over a wide range of UF, t, and R values. Based on the mURR equation, mURR values of 64%, 70%, and 76% are mathematically equivalent to spKt/V levels of 1.0, 1.2, and 1.4, respectively. This equation can be a useful bedside tool to quantify hemodialysis dose.
Y L Cheng; K S Choi; K F Chau; C S Li; C U Yung; A W Yu; K K Wong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  37     ISSN:  1523-6838     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-06     Completed Date:  2001-03-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  544-9     Citation Subset:  IM    
Department of Medicine, North District Hospital, Queen Elizabeth Hospital, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, China.
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MeSH Terms
Blood Urea Nitrogen
Renal Dialysis*
Urea / metabolism*
Reg. No./Substance:

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