Document Detail

Urea kinetic modelling by partial dialysate collection.
MedLine Citation:
PMID:  2707909     Owner:  NLM     Status:  MEDLINE    
Conventional urea kinetic modelling (UKM) has several drawbacks, in particular the complexity of the required calculations and the need for accurate values of parameters which are difficult to measure, such as dialyzer clearance and blood flow. An alternative method of UKM is proposed based on collecting a small fraction of spent dialysate flow for 3 consecutive dialyses. Application of a urea mass balance to the 7 day period permits neglecting changes in body urea stores. Thus no blood sampling is required for most patients. The required calculations are simple and straightforward. The partial dialysate collection (PDC) method was compared to conventional UKM in a 3 patient, 15 week study. Protein catabolic rate (PCR) from PDC was a smooth curve and consistent with dietary estimation for each patient. Conventional UKM gave variable PCR results which were 17-27% higher on average. This discrepancy was attributed to overestimation of dialyzer clearance. PDC was concluded to be more convenient and accurate than conventional UKM and therefore ideal for routine clinical use.
L J Garred; M Rittau; W McCready; B Canaud
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The International journal of artificial organs     Volume:  12     ISSN:  0391-3988     ISO Abbreviation:  Int J Artif Organs     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-05-26     Completed Date:  1989-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802649     Medline TA:  Int J Artif Organs     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  96-102     Citation Subset:  IM    
Lakehead University, Ontario, Canada.
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MeSH Terms
Blood Flow Velocity
Computer Simulation*
Kidney, Artificial
Middle Aged
Renal Dialysis*
Urea / blood*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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