Document Detail

Urea and dilatation of the cervix.
MedLine Citation:
PMID:  31093     Owner:  NLM     Status:  MEDLINE    
The minimal elasticity of the uterine cervix has been related to its high collagen content. By interfering with cohesive forces that hold the collagen fiber bundle together, it is possible to diminish the physical strength of collagen. Urea has been used in collagen chemistry to dissociate collagen by interfering with hydrophobic linkages and hydrogen bonds. This results in a change of mechanical properties such as a decrease in tensile strength and an increase in elasticity. Basic studies of rat tail tendon demonstrated the additive effects of pH, concentration of urea, and temperature on the mechanical characteristics of collagen fibers. In vitro testing was performed using an injection of 30 per cent urea at pH 4. Serial measurements with a spring gauge instrument showed a reduction in cervical resistance. A cervical injection technique has been developed and toxicity of urea studied.
W Droegemueller; M Chvapil; J Vining; L Whitaker; C D Christian
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  132     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-01-24     Completed Date:  1979-01-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  775-82     Citation Subset:  AIM; IM    
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MeSH Terms
Cervix Uteri / drug effects*,  physiology
Connective Tissue / drug effects*
Hydrogen Bonding
Hydrogen-Ion Concentration
Injections, Subcutaneous
Stress, Mechanical
Tensile Strength / drug effects
Urea / administration & dosage,  pharmacology*,  toxicity
Reg. No./Substance:
57-13-6/Urea; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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