| Urea clearance: a new technique based on microdialysis to assess liver blood flow studied in a pig model of ischemia/reperfusion. | |
| | |
MedLine Citation:
|
PMID: 20861637 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Delayed detection of ischemia is one of the most feared postoperative complications. Early detection of impaired blood flow and close monitoring of the organ-specific metabolic status may therefore be critical for the surgical outcome. Urea clearance is a new technique for continuous monitoring of alterations in blood flow and metabolic markers with acceptable temporal characteristics. We compare this new microdialysis technique with the established microdialysis ethanol technique to assess hepatic blood flow. Six pigs were used in a liver ischemia/reperfusion injury model. Microdialysis catheters were placed in liver segment IV and all circulation was stopped for 80 min, followed by reperfusion for 220 min. Urea and ethanol clearance was calculated from the dialysate and correlated with metabolic changes. A laser Doppler probe was used as reference of restoration of blood flow. Both urea and ethanol clearance reproducibly depicted changes in liver blood flow in relation to metabolic changes and laser Doppler measurements. The two techniques highly correlated both overall and during the reperfusion phase (r = 0.8) and the changes were paralleled by altered perfusion as recorded by laser Doppler. |
| | |
Authors:
|
S Farnebo; A Winbladh; E K Zettersten; P Sandström; P Gullstrand; A Samuelsson; E Theodorson; F Sjöberg |
Related Documents
:
|
10374407 - Effect of mild hypothermia on the changes of cerebral blood flow, brain blood barrier a... 18350127 - In vivo evaluation of the nitroimidazole-based thioflavin-t derivatives as cerebral isc... 3139367 - Resuscitation potentials after prolonged global cerebral ischemia in cats. 6881567 - Evaluation of the myotoxicity of bupivacaine in bier blocks--a biochemical and electron... 11377457 - Three common assumptions about ocular blood flow and glaucoma. 12595297 - Cerebral artery responses to pressure and flow in uremic hypertensive and spontaneously... |
Publication Detail:
|
Type: Journal Article Date: 2010-09-23 |
Journal Detail:
|
Title: European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes Volume: 45 ISSN: 1421-9921 ISO Abbreviation: Eur Surg Res Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-10-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0174752 Medline TA: Eur Surg Res Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 105-12 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 S. Karger AG, Basel. |
Affiliation:
|
Department of Hand Surgery, Plastic Surgery and Burns, Linköping University Hospital, Linköping, Sweden. simon.farnebo @ lio.se |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Association between non-diminutive hyperplastic polyps and synchronous advanced colorectal neoplasms...
Next Document: Peanut allergy--a tough nut to crack.