| Urban land-use and respiratory symptoms in infants. | |
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MedLine Citation:
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PMID: 21530957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Children's respiratory health has been linked to many factors, including air pollution. The impacts of urban land-use on health are not fully understood, although these relationships are of key importance given the growing populations living in urban environments. OBJECTIVES: We investigated whether the degree of urban land-use near a family's residence is associated with severity of respiratory symptoms like wheeze among infants. METHODS: Wheeze occurrence was recorded for the first year of life for 680 infants in Connecticut for 1996-1998 from a cohort at risk for asthma development. Land-use categories were obtained from the National Land Cover Database. The fraction of urban land-use near each subject's home was related to severity of wheeze symptoms using ordered logistic regression, adjusting for individual-level data including smoking in the household, race, gender, and socio-economic status. Nitrogen dioxide (NO(2)) exposure was estimated using integrated traffic exposure modeling. Different levels of urban land-use intensity were included in separate models to explore intensity-response relationships. A buffer distance was selected based on the log-likelihood value of models with buffers of 100-2000 m by 10 m increments. RESULTS: A 10% increase in urban land-use within the selected 1540 m buffer of each infant's residence was associated with 1.09-fold increased risk of wheeze severity (95% confidence interval, 1.02-1.16). Results were robust to alternate buffer sizes. When NO(2), representing traffic pollution, was added to the model, results for urban land-use were no longer statistically significant, but had similar central estimates. Higher urban intensity showed higher risk of prevalence and severity of wheeze symptoms. CONCLUSIONS: Urban land-use was associated with severity of wheeze symptoms in infants. Findings indicate that health effect estimates for urbanicity incorporate some effects of traffic-related emissions, but also involve other factors. These may include differences in housing characteristics or baseline healthcare status. |
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Authors:
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Keita Ebisu; Theodore R Holford; Kathleen D Belanger; Brian P Leaderer; Michelle L Bell |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-04-29 |
Journal Detail:
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Title: Environmental research Volume: 111 ISSN: 1096-0953 ISO Abbreviation: Environ. Res. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-13 Completed Date: 2011-08-08 Revised Date: 2012-09-20 |
Medline Journal Info:
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Nlm Unique ID: 0147621 Medline TA: Environ Res Country: United States |
Other Details:
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Languages: eng Pagination: 677-84 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Yale University, School of Forestry and Environmental Studies, New Haven, CT 06511, USA. keita.ebisu@aya.yale.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Air Pollution
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statistics & numerical data Asthma / epidemiology* Cities / statistics & numerical data* Connecticut / epidemiology Environmental Exposure / analysis, statistics & numerical data* Female Geographic Information Systems Humans Infant Infant, Newborn Male Nitrogen Dioxide / analysis Odds Ratio Particle Size Particulate Matter / analysis Respiratory Sounds* Social Class |
| Grant Support | |
ID/Acronym/Agency:
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ES05410/ES/NIEHS NIH HHS; ES07456/ES/NIEHS NIH HHS; R01 ES005410-18/ES/NIEHS NIH HHS; R01 ES007456-11/ES/NIEHS NIH HHS; R01 ES016317-04/ES/NIEHS NIH HHS; R01 ES016317-05/ES/NIEHS NIH HHS; R01 ES017416-04/ES/NIEHS NIH HHS; R01ES07456/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Particulate Matter; 10102-44-0/Nitrogen Dioxide |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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