Document Detail


Urban land-use and respiratory symptoms in infants.
MedLine Citation:
PMID:  21530957     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Children's respiratory health has been linked to many factors, including air pollution. The impacts of urban land-use on health are not fully understood, although these relationships are of key importance given the growing populations living in urban environments.
OBJECTIVES: We investigated whether the degree of urban land-use near a family's residence is associated with severity of respiratory symptoms like wheeze among infants.
METHODS: Wheeze occurrence was recorded for the first year of life for 680 infants in Connecticut for 1996-1998 from a cohort at risk for asthma development. Land-use categories were obtained from the National Land Cover Database. The fraction of urban land-use near each subject's home was related to severity of wheeze symptoms using ordered logistic regression, adjusting for individual-level data including smoking in the household, race, gender, and socio-economic status. Nitrogen dioxide (NO(2)) exposure was estimated using integrated traffic exposure modeling. Different levels of urban land-use intensity were included in separate models to explore intensity-response relationships. A buffer distance was selected based on the log-likelihood value of models with buffers of 100-2000 m by 10 m increments.
RESULTS: A 10% increase in urban land-use within the selected 1540 m buffer of each infant's residence was associated with 1.09-fold increased risk of wheeze severity (95% confidence interval, 1.02-1.16). Results were robust to alternate buffer sizes. When NO(2), representing traffic pollution, was added to the model, results for urban land-use were no longer statistically significant, but had similar central estimates. Higher urban intensity showed higher risk of prevalence and severity of wheeze symptoms.
CONCLUSIONS: Urban land-use was associated with severity of wheeze symptoms in infants. Findings indicate that health effect estimates for urbanicity incorporate some effects of traffic-related emissions, but also involve other factors. These may include differences in housing characteristics or baseline healthcare status.
Authors:
Keita Ebisu; Theodore R Holford; Kathleen D Belanger; Brian P Leaderer; Michelle L Bell
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-04-29
Journal Detail:
Title:  Environmental research     Volume:  111     ISSN:  1096-0953     ISO Abbreviation:  Environ. Res.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-13     Completed Date:  2011-08-08     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  677-84     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Air Pollution / statistics & numerical data
Asthma / epidemiology*
Cities / statistics & numerical data*
Connecticut / epidemiology
Environmental Exposure / analysis,  statistics & numerical data*
Female
Geographic Information Systems
Humans
Infant
Infant, Newborn
Male
Nitrogen Dioxide / analysis
Odds Ratio
Particle Size
Particulate Matter / analysis
Respiratory Sounds*
Social Class
Grant Support
ID/Acronym/Agency:
ES05410/ES/NIEHS NIH HHS; ES07456/ES/NIEHS NIH HHS; R01 ES005410/ES/NIEHS NIH HHS; R01 ES005410-18/ES/NIEHS NIH HHS; R01 ES007456/ES/NIEHS NIH HHS; R01 ES007456-11/ES/NIEHS NIH HHS; R01 ES016317/ES/NIEHS NIH HHS; R01 ES016317-04/ES/NIEHS NIH HHS; R01 ES017416/ES/NIEHS NIH HHS; R01ES07456/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Particulate Matter; S7G510RUBH/Nitrogen Dioxide
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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