Document Detail


Urapidil in normotensive and spontaneously hypertensive rats: the effects on systemic and regional haemodynamics and cardiac mass.
MedLine Citation:
PMID:  6530543     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of treatment for three weeks with urapidil (10 mg/kg p.o. twice daily) on systemic and regional haemodynamics and cardiac mass were studied in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). Urapidil decreased mean arterial pressure and total peripheral resistance index (176 +/- 3 versus 145 +/- 5 mmHg and 0.61 +/- 0.02 versus 0.49 +/- 0.02 units, respectively; each P less than 0.01) in SHR without affecting heart rate, cardiac index or cardiac mass. No systemic haemodynamic changes were observed in WKY rats. All organ vascular resistances decreased significantly in SHR and blood flow increased to skin (P less than 0.01) and kidneys (P less than 0.05). These data indicate that urapidil is a potent antihypertensive agent in SHR which reduced mean arterial pressure through a decreased total peripheral resistance that was distributed throughout all circulations. Despite these haemodynamic changes, cardiac mass did not change.
Authors:
I Kobrin; A J Gallo; B L Pegram; E D Frohlich
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  2     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1985-04-26     Completed Date:  1985-04-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  317-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antihypertensive Agents / pharmacology*
Blood Pressure / drug effects*
Heart / drug effects*
Heart Rate / drug effects
Hemodynamics / drug effects*
Hypertension / drug therapy*,  pathology,  physiopathology
Male
Organ Size / drug effects
Piperazines / pharmacology,  therapeutic use*
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Piperazines; 34661-75-1/urapidil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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